Entresto
E584152
Entresto is a prescription heart failure medication that combines sacubitril and valsartan to reduce the risk of cardiovascular death and hospitalization.
Statements (46)
| Predicate | Object |
|---|---|
| instanceOf |
brand name medication
ⓘ
pharmaceutical drug ⓘ |
| actsOn | renin-angiotensin-aldosterone system ⓘ |
| ATCCode | C09DX04 ⓘ |
| blackBoxWarning | fetal toxicity ⓘ |
| containsSubstanceRole |
angiotensin II receptor blocker
ⓘ
neprilysin inhibitor ⓘ |
| contraindication |
concomitant use with ACE inhibitors
ⓘ
history of angioedema related to ACE inhibitor or ARB therapy ⓘ pregnancy ⓘ |
| developer | Novartis NERFINISHED ⓘ |
| drugClass |
ARNI
ⓘ
angiotensin receptor neprilysin inhibitor ⓘ |
| effect |
reduces cardiovascular mortality in heart failure patients
ⓘ
reduces hospitalization for heart failure ⓘ |
| hasActiveIngredient |
sacubitril
ⓘ
valsartan ⓘ |
| hasComponentOfFixedDoseCombination |
sacubitril
ⓘ
valsartan ⓘ |
| hasDosageForm | film-coated tablet ⓘ |
| indication |
chronic heart failure
ⓘ
heart failure with reduced ejection fraction ⓘ reduction of risk of cardiovascular death and hospitalization for heart failure ⓘ |
| legalStatusEU | prescription only medicine ⓘ |
| legalStatusUS | Rx-only ⓘ |
| marketingAuthorizationHolder | Novartis NERFINISHED ⓘ |
| mechanismOfAction |
blocks angiotensin II type 1 receptors
ⓘ
inhibits neprilysin to increase natriuretic peptides ⓘ |
| pregnancyCategory | contraindicated in pregnancy ⓘ |
| prescriptionStatus | prescription only ⓘ |
| regulatoryStatus |
EMA approved
ⓘ
FDA approved ⓘ |
| requiresWashoutPeriodWith | ACE inhibitors ⓘ |
| routeOfAdministration | oral ⓘ |
| sideEffect |
cough
ⓘ
dizziness ⓘ hyperkalemia ⓘ hypotension ⓘ renal impairment ⓘ |
| targetPopulation | adult patients with chronic heart failure ⓘ |
| therapeuticArea |
cardiology
ⓘ
heart failure management ⓘ |
| warning |
impaired renal function
ⓘ
risk of angioedema ⓘ risk of hyperkalemia ⓘ risk of hypotension ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.