CYP2C19
E567681
CYP2C19 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs, including certain antidepressants, proton pump inhibitors, and antiplatelet agents.
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
cytochrome P450 enzyme
ⓘ
drug-metabolizing enzyme ⓘ enzyme ⓘ protein-coding gene product ⓘ |
| affects |
plasma concentration of certain antidepressants
ⓘ
plasma concentration of proton pump inhibitors ⓘ response to clopidogrel ⓘ |
| belongsToFamily | cytochrome P450 family 2 ⓘ |
| belongsToSubfamily | cytochrome P450 subfamily C NERFINISHED ⓘ |
| clinicalRelevance |
dose adjustment of certain antidepressants
ⓘ
dose adjustment of proton pump inhibitors ⓘ personalized medicine ⓘ pharmacogenomics ⓘ |
| encodedBy | CYP2C19 gene ⓘ |
| fullName | cytochrome P450 family 2 subfamily C member 19 NERFINISHED ⓘ |
| hasFunction |
drug metabolism
ⓘ
oxidation of xenobiotics ⓘ xenobiotic metabolism ⓘ |
| hasMolecularFunction |
monooxygenase activity
ⓘ
oxidoreductase activity ⓘ |
| hasPolymorphism |
CYP2C19*1
ⓘ
CYP2C19*17 NERFINISHED ⓘ CYP2C19*2 NERFINISHED ⓘ CYP2C19*3 NERFINISHED ⓘ |
| highExpressionSite | liver ⓘ |
| inhibitedBy |
fluvoxamine
ⓘ
omeprazole NERFINISHED ⓘ |
| isKeyFor | bioactivation of clopidogrel ⓘ |
| locatedIn | endoplasmic reticulum ⓘ |
| metabolizes |
amitriptyline
ⓘ
citalopram NERFINISHED ⓘ clopidogrel ⓘ diazepam ⓘ escitalopram ⓘ imipramine ⓘ lansoprazole ⓘ mephenytoin NERFINISHED ⓘ omeprazole NERFINISHED ⓘ pantoprazole ⓘ phenytoin ⓘ proguanil ⓘ voriconazole ⓘ |
| organism | Homo sapiens NERFINISHED ⓘ |
| pathway | phase I drug metabolism ⓘ |
| usesCofactor |
NADPH
ⓘ
heme ⓘ |
| variationConsequence |
extensive metabolizer phenotype
ⓘ
intermediate metabolizer phenotype ⓘ poor metabolizer phenotype ⓘ ultrarapid metabolizer phenotype ⓘ |
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.