Aubagio
E561778
Aubagio is a prescription oral medication (teriflunomide) used to treat relapsing forms of multiple sclerosis in adults.
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
brand name drug
ⓘ
disease-modifying therapy for multiple sclerosis ⓘ pharmaceutical drug ⓘ |
| hasActiveIngredient | teriflunomide NERFINISHED ⓘ |
| hasATCCode | L04AA31 ⓘ |
| hasBlackBoxWarning |
embryo-fetal toxicity
ⓘ
hepatotoxicity ⓘ |
| hasBoxedWarningRegion | United States NERFINISHED ⓘ |
| hasDosageForm | oral tablet ⓘ |
| hasEffect |
reduces relapse rate in relapsing multiple sclerosis
ⓘ
slows accumulation of physical disability in multiple sclerosis ⓘ |
| hasEliminationProcedure |
activated charcoal washout
ⓘ
cholestyramine washout ⓘ |
| hasGenericName | teriflunomide NERFINISHED ⓘ |
| hasIndicationPopulation | adults ⓘ |
| hasLongHalfLife | true ⓘ |
| hasPharmacologicClass |
immunomodulator
ⓘ
pyrimidine synthesis inhibitor ⓘ |
| hasPregnancyCategory | contraindicated ⓘ |
| hasRegulatoryAgencyApproval |
European Medicines Agency
NERFINISHED
ⓘ
U.S. Food and Drug Administration NERFINISHED ⓘ |
| hasRisk |
infections due to immunosuppression
ⓘ
serious liver injury ⓘ serious skin reactions ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| hasRouteOfElimination | hepatic ⓘ |
| hasTeratogenicRisk | true ⓘ |
| isAdministeredOnceDaily | true ⓘ |
| isContraindicatedIn |
pregnancy
ⓘ
severe hepatic impairment ⓘ |
| isMarketedBy | Sanofi NERFINISHED ⓘ |
| isMetabolizedIn | liver ⓘ |
| isPrescriptionDrug | true ⓘ |
| isTakenWithFood | may be taken with or without food ⓘ |
| isUsedFor |
active secondary progressive multiple sclerosis
ⓘ
clinically isolated syndrome (CIS) ⓘ relapsing forms of multiple sclerosis ⓘ relapsing-remitting multiple sclerosis ⓘ |
| mayCause |
alopecia (hair thinning)
ⓘ
diarrhea ⓘ elevated liver enzymes ⓘ hypertension ⓘ nausea ⓘ peripheral neuropathy ⓘ |
| mechanismOfAction |
inhibits dihydroorotate dehydrogenase (DHODH)
ⓘ
reduces proliferation of activated T and B lymphocytes ⓘ |
| requiresMonitoring |
blood pressure
ⓘ
liver function tests ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.