Plavix
E561776
Plavix is a widely used prescription antiplatelet medication (clopidogrel) that helps prevent blood clots and reduce the risk of heart attack and stroke.
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
P2Y12 inhibitor
ⓘ
antiplatelet medication ⓘ brand name drug ⓘ pharmaceutical drug ⓘ |
| affects | platelet function ⓘ |
| approvedBy | U.S. Food and Drug Administration NERFINISHED ⓘ |
| coMarketedBy | Bristol-Myers Squibb NERFINISHED ⓘ |
| contraindication |
active pathological bleeding
ⓘ
severe hepatic impairment ⓘ |
| developedBy | Sanofi NERFINISHED ⓘ |
| doesNotAffect | coagulation factors directly ⓘ |
| hasActiveIngredient | clopidogrel bisulfate ⓘ |
| hasATCCode | B01AC04 ⓘ |
| hasBlackBoxWarning | reduced effectiveness in CYP2C19 poor metabolizers ⓘ |
| hasCommonDrugInteraction |
esomeprazole
NERFINISHED
ⓘ
omeprazole ⓘ |
| hasDosageForm | film-coated tablet ⓘ |
| hasDrugClass | thienopyridine ⓘ |
| hasDurationOfEffect | platelet inhibition lasts for platelet lifespan ⓘ |
| hasEffect |
inhibits platelet aggregation
ⓘ
reduces blood clot formation ⓘ |
| hasFDAApprovalYear | 1997 ⓘ |
| hasGenericName | clopidogrel ⓘ |
| hasLegalStatusEU | prescription only ⓘ |
| hasLegalStatusUS | prescription only ⓘ |
| hasMechanismOfAction | irreversible inhibition of platelet P2Y12 ADP receptor ⓘ |
| hasOnsetOfAction | within hours after loading dose ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| hasTypicalStrength |
300 mg tablet
ⓘ
75 mg tablet ⓘ |
| isPrescriptionOnly | true ⓘ |
| isProdrug | true ⓘ |
| majorAdverseEffect |
bleeding
ⓘ
gastrointestinal bleeding ⓘ thrombocytopenia ⓘ |
| metabolizedBy |
CYP2C19
NERFINISHED
ⓘ
CYP3A4 ⓘ |
| oftenUsedWith | aspirin ⓘ |
| pregnancyCategoryUS | B ⓘ |
| rareAdverseEffect | thrombotic thrombocytopenic purpura ⓘ |
| reducesRiskOf |
heart attack
ⓘ
stroke ⓘ vascular death ⓘ |
| requires | hepatic bioactivation ⓘ |
| takenHowOften | once daily ⓘ |
| usedFor |
acute coronary syndrome
ⓘ
management of peripheral arterial disease ⓘ prevention of atherothrombotic events ⓘ prevention of stent thrombosis ⓘ secondary prevention of ischemic stroke ⓘ secondary prevention of myocardial infarction ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.