one gene–one enzyme hypothesis
E561767
The one gene–one enzyme hypothesis is a foundational concept in genetics proposing that each gene encodes a specific enzyme that affects a single step in a metabolic pathway.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| Genetic control of biochemical reactions in Neurospora | 1 |
Statements (44)
| Predicate | Object |
|---|---|
| instanceOf |
concept in molecular biology
ⓘ
genetic hypothesis ⓘ historical scientific theory ⓘ |
| associatedAward | Nobel Prize in Physiology or Medicine 1958 NERFINISHED ⓘ |
| associatedLaureate |
Edward Tatum
NERFINISHED
ⓘ
George Beadle NERFINISHED ⓘ |
| basedOn | experiments with Neurospora crassa ⓘ |
| category |
history of genetics
ⓘ
scientific models ⓘ |
| clarified | functional role of genes in metabolism ⓘ |
| consequence | established genes as determinants of specific biochemical steps ⓘ |
| coreIdea |
each enzyme affects a single step in a metabolic pathway
ⓘ
each gene encodes a specific enzyme ⓘ |
| demonstratedBy | correlation between specific mutations and specific enzymatic defects ⓘ |
| field |
biochemistry
ⓘ
genetics ⓘ molecular biology ⓘ |
| hasImplication |
genotype can be inferred from metabolic phenotype
ⓘ
mutant phenotypes can map to specific biochemical steps ⓘ |
| historicalContext | pre-DNA era of genetics ⓘ |
| historicalPrecursor | concept of inborn errors of metabolism ⓘ |
| influenced |
development of molecular genetics
ⓘ
understanding of gene–protein relationships ⓘ |
| inspiredBy | Archibald Garrod's work on inborn errors of metabolism ⓘ |
| limitation |
genes can produce multiple polypeptides via alternative splicing
ⓘ
not all gene products are enzymes ⓘ some enzymes consist of multiple polypeptide subunits encoded by different genes ⓘ some genes encode functional RNAs rather than proteins ⓘ |
| proposedBy |
Edward Tatum
NERFINISHED
ⓘ
George Beadle NERFINISHED ⓘ |
| refinedTo |
one gene–one RNA hypothesis
ⓘ
one gene–one polypeptide hypothesis ⓘ |
| relatedConcept |
central dogma of molecular biology
ⓘ
gene expression ⓘ metabolic genetics ⓘ |
| relatesTo |
enzyme specificity
ⓘ
gene function ⓘ metabolic pathways ⓘ |
| status | historically important but oversimplified ⓘ |
| supports | link between genes and biochemical reactions ⓘ |
| teaches | mutations in a single gene can block a specific metabolic step ⓘ |
| testedIn | auxotrophic mutants of Neurospora crassa ⓘ |
| usedIn | early biochemical genetics research ⓘ |
| yearProposed | 1941 ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
Genetic control of biochemical reactions in Neurospora