one gene–one enzyme hypothesis
E561767
The one gene–one enzyme hypothesis is a foundational concept in genetics proposing that each gene encodes a specific enzyme that affects a single step in a metabolic pathway.
All labels observed (2)
| Label | Occurrences |
|---|---|
| Genetic control of biochemical reactions in Neurospora | 1 |
| one gene–one enzyme hypothesis canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6005948 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: one gene–one enzyme hypothesis Context triple: [Neurospora crassa, historicallyImportantExperiment, one gene–one enzyme hypothesis]
-
A.
The Theory of the Gene
The Theory of the Gene is a foundational 1926 book by geneticist Thomas Hunt Morgan that synthesized experimental evidence to establish chromosomes and genes as the physical basis of heredity.
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B.
Molecular Biology of the Gene
Molecular Biology of the Gene is a landmark molecular biology textbook, co-authored by James Watson, that helped define and systematize modern understanding of DNA structure, gene function, and genetic regulation.
-
C.
Haldane–Oparin hypothesis of the origin of life
The Haldane–Oparin hypothesis of the origin of life proposes that life first arose through a gradual chemical evolution of organic molecules in Earth’s early “primordial soup,” eventually leading to self-replicating systems.
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D.
Luria–Delbrück experiment
The Luria–Delbrück experiment was a landmark 1943 study in bacterial genetics that demonstrated mutations arise randomly rather than in response to selective pressure, providing key evidence for the genetic basis of evolution.
-
E.
The Mechanism of Mendelian Heredity
The Mechanism of Mendelian Heredity is a foundational early 20th-century genetics book that established the chromosome theory of inheritance through experimental work with fruit flies.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: one gene–one enzyme hypothesis Target entity description: The one gene–one enzyme hypothesis is a foundational concept in genetics proposing that each gene encodes a specific enzyme that affects a single step in a metabolic pathway.
-
A.
The Theory of the Gene
The Theory of the Gene is a foundational 1926 book by geneticist Thomas Hunt Morgan that synthesized experimental evidence to establish chromosomes and genes as the physical basis of heredity.
-
B.
Molecular Biology of the Gene
Molecular Biology of the Gene is a landmark molecular biology textbook, co-authored by James Watson, that helped define and systematize modern understanding of DNA structure, gene function, and genetic regulation.
-
C.
Haldane–Oparin hypothesis of the origin of life
The Haldane–Oparin hypothesis of the origin of life proposes that life first arose through a gradual chemical evolution of organic molecules in Earth’s early “primordial soup,” eventually leading to self-replicating systems.
-
D.
Luria–Delbrück experiment
The Luria–Delbrück experiment was a landmark 1943 study in bacterial genetics that demonstrated mutations arise randomly rather than in response to selective pressure, providing key evidence for the genetic basis of evolution.
-
E.
The Mechanism of Mendelian Heredity
The Mechanism of Mendelian Heredity is a foundational early 20th-century genetics book that established the chromosome theory of inheritance through experimental work with fruit flies.
- F. None of above. chosen
Statements (44)
| Predicate | Object |
|---|---|
| instanceOf |
concept in molecular biology
ⓘ
genetic hypothesis ⓘ historical scientific theory ⓘ |
| associatedAward | Nobel Prize in Physiology or Medicine 1958 NERFINISHED ⓘ |
| associatedLaureate |
Edward Tatum
NERFINISHED
ⓘ
George Beadle NERFINISHED ⓘ |
| basedOn | experiments with Neurospora crassa ⓘ |
| category |
history of genetics
ⓘ
scientific models ⓘ |
| clarified | functional role of genes in metabolism ⓘ |
| consequence | established genes as determinants of specific biochemical steps ⓘ |
| coreIdea |
each enzyme affects a single step in a metabolic pathway
ⓘ
each gene encodes a specific enzyme ⓘ |
| demonstratedBy | correlation between specific mutations and specific enzymatic defects ⓘ |
| field |
biochemistry
ⓘ
genetics ⓘ molecular biology ⓘ |
| hasImplication |
genotype can be inferred from metabolic phenotype
ⓘ
mutant phenotypes can map to specific biochemical steps ⓘ |
| historicalContext | pre-DNA era of genetics ⓘ |
| historicalPrecursor | concept of inborn errors of metabolism ⓘ |
| influenced |
development of molecular genetics
ⓘ
understanding of gene–protein relationships ⓘ |
| inspiredBy | Archibald Garrod's work on inborn errors of metabolism ⓘ |
| limitation |
genes can produce multiple polypeptides via alternative splicing
ⓘ
not all gene products are enzymes ⓘ some enzymes consist of multiple polypeptide subunits encoded by different genes ⓘ some genes encode functional RNAs rather than proteins ⓘ |
| proposedBy |
Edward Tatum
NERFINISHED
ⓘ
George Beadle NERFINISHED ⓘ |
| refinedTo |
one gene–one RNA hypothesis
ⓘ
one gene–one polypeptide hypothesis ⓘ |
| relatedConcept |
central dogma of molecular biology
ⓘ
gene expression ⓘ metabolic genetics ⓘ |
| relatesTo |
enzyme specificity
ⓘ
gene function ⓘ metabolic pathways ⓘ |
| status | historically important but oversimplified ⓘ |
| supports | link between genes and biochemical reactions ⓘ |
| teaches | mutations in a single gene can block a specific metabolic step ⓘ |
| testedIn | auxotrophic mutants of Neurospora crassa ⓘ |
| usedIn | early biochemical genetics research ⓘ |
| yearProposed | 1941 ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: one gene–one enzyme hypothesis Description of subject: The one gene–one enzyme hypothesis is a foundational concept in genetics proposing that each gene encodes a specific enzyme that affects a single step in a metabolic pathway.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
Genetic control of biochemical reactions in Neurospora