WDR41
E561101
WDR41 is a WD repeat-containing protein implicated in autophagy and lysosomal function, often studied in the context of neurodegenerative disease–related pathways.
Statements (45)
| Predicate | Object |
|---|---|
| instanceOf |
human gene
ⓘ
protein ⓘ |
| associatedWith |
autophagy-related signaling pathways
ⓘ
lysosomal storage pathways ⓘ mTOR signaling regulation ⓘ neurodegenerative disease–related pathways ⓘ |
| binds |
PIKfyve
NERFINISHED
ⓘ
VAC14 ⓘ lysosomal membranes ⓘ |
| conservedIn | vertebrates ⓘ |
| containsDomain | WD repeat domain ⓘ |
| encodes | WD repeat-containing protein 41 ⓘ |
| expressedIn |
human brain
ⓘ
multiple human tissues ⓘ neurons ⓘ |
| geneType | protein-coding gene ⓘ |
| hasFullName | WD repeat domain 41 NERFINISHED ⓘ |
| hasGeneSymbol | WDR41 ⓘ |
| hasMolecularFunction |
protein binding
ⓘ
scaffold protein activity ⓘ |
| hasProteinFeature | beta-propeller structure ⓘ |
| hasRepeatType | WD40 repeat ⓘ |
| involvedIn |
autophagosome-lysosome fusion
ⓘ
autophagy ⓘ lysosomal function ⓘ lysosome biogenesis ⓘ macroautophagy ⓘ neuronal homeostasis ⓘ |
| locatedOnChromosome | human chromosome 5 ⓘ |
| lossOfFunctionPhenotype |
accumulation of autophagic substrates
ⓘ
defective lysosomal function ⓘ impaired autophagic flux ⓘ |
| orthologIn |
mouse Wdr41
ⓘ
zebrafish wdr41 ⓘ |
| participatesIn |
endosomal-lysosomal pathway
ⓘ
phosphoinositide metabolism regulation ⓘ |
| participatesInComplex | PIKfyve-VAC14-FIG4 complex ⓘ |
| regulates |
endolysosomal trafficking
ⓘ
lysosomal nutrient sensing ⓘ |
| studiedInContextOf |
ALS-related pathways
ⓘ
Parkinson disease–related pathways ⓘ |
| subcellularLocation |
cytoplasm
ⓘ
endolysosomal compartment ⓘ lysosome ⓘ |
| taxon | Homo sapiens NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.