LSm proteins
E561091
LSm proteins are a family of conserved RNA-binding proteins that form ring-shaped complexes involved in pre-mRNA splicing and mRNA processing in eukaryotic cells.
All labels observed (1)
| Label | Occurrences |
|---|---|
| LSm proteins canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6004698 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: LSm proteins Context triple: [Survival motor neuron protein, interactsWith, LSm proteins]
-
A.
LMB
LMB is a commonly used abbreviation that can refer to various organizations or concepts, most notably the MRC Laboratory of Molecular Biology in Cambridge, UK.
-
B.
LSMD
LSMD is the ICAO airport code assigned to Dübendorf Air Base in Switzerland.
-
C.
TARDBP
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
-
D.
Lm
Lm is the currency symbol that was used to denote the Maltese lira, Malta’s former national currency before adoption of the euro.
-
E.
LGC
LGC is the three-letter IATA airport code for LaGrange–Callaway Airport in LaGrange, Georgia, United States.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: LSm proteins Target entity description: LSm proteins are a family of conserved RNA-binding proteins that form ring-shaped complexes involved in pre-mRNA splicing and mRNA processing in eukaryotic cells.
-
A.
LMB
LMB is a commonly used abbreviation that can refer to various organizations or concepts, most notably the MRC Laboratory of Molecular Biology in Cambridge, UK.
-
B.
LSMD
LSMD is the ICAO airport code assigned to Dübendorf Air Base in Switzerland.
-
C.
TARDBP
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
-
D.
Lm
Lm is the currency symbol that was used to denote the Maltese lira, Malta’s former national currency before adoption of the euro.
-
E.
LGC
LGC is the three-letter IATA airport code for LaGrange–Callaway Airport in LaGrange, Georgia, United States.
- F. None of above. chosen
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
RNA-binding protein
ⓘ
protein family ⓘ ribonucleoprotein component ⓘ |
| associatedWith |
U-rich small nuclear RNAs
ⓘ
U6 snRNP core ⓘ |
| bindsMolecule |
RNA
ⓘ
U-rich 3′ ends of RNA ⓘ uridine-rich RNA ⓘ |
| containsDomain | Sm-like fold ⓘ |
| containsMotif |
Sm1 motif
ⓘ
Sm2 motif ⓘ |
| evolutionaryOrigin | derived from ancestral Sm proteins ⓘ |
| formsComplex |
LSm1–7 complex
NERFINISHED
ⓘ
LSm2–8 complex NERFINISHED ⓘ heptameric ring ⓘ heteroheptameric complex ⓘ |
| formsComplexWith |
U6 snRNA
NERFINISHED
ⓘ
mRNA decay factors ⓘ other Sm/LSm proteins ⓘ pre-mRNA ⓘ |
| foundIn |
archaea
ⓘ
eukaryotic cells ⓘ |
| geneFamilyMembers |
LSM1
NERFINISHED
ⓘ
LSM2 NERFINISHED ⓘ LSM3 ⓘ LSM4 NERFINISHED ⓘ LSM5 ⓘ LSM6 NERFINISHED ⓘ LSM7 ⓘ LSM8 NERFINISHED ⓘ |
| hasCharacteristic |
RNA-binding
ⓘ
eukaryote-wide distribution ⓘ highly conserved ⓘ oligomeric ⓘ ring-shaped complex-forming ⓘ |
| localization |
P-bodies
ⓘ
U6 snRNP NERFINISHED ⓘ cytoplasm ⓘ nucleus ⓘ spliceosome ⓘ |
| participatesIn |
RNA metabolism
ⓘ
RNA quality control ⓘ U6 snRNP assembly ⓘ mRNA decay ⓘ mRNA processing ⓘ mRNA stabilization ⓘ pre-mRNA splicing ⓘ spliceosome assembly ⓘ translation regulation ⓘ |
| sharesHomologyWith | canonical Sm proteins ⓘ |
| subClassOf | Sm-like proteins NERFINISHED ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: LSm proteins Description of subject: LSm proteins are a family of conserved RNA-binding proteins that form ring-shaped complexes involved in pre-mRNA splicing and mRNA processing in eukaryotic cells.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Survival motor neuron protein