LSm proteins
E561091
LSm proteins are a family of conserved RNA-binding proteins that form ring-shaped complexes involved in pre-mRNA splicing and mRNA processing in eukaryotic cells.
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
RNA-binding protein
ⓘ
protein family ⓘ ribonucleoprotein component ⓘ |
| associatedWith |
U-rich small nuclear RNAs
ⓘ
U6 snRNP core ⓘ |
| bindsMolecule |
RNA
ⓘ
U-rich 3′ ends of RNA ⓘ uridine-rich RNA ⓘ |
| containsDomain | Sm-like fold ⓘ |
| containsMotif |
Sm1 motif
ⓘ
Sm2 motif ⓘ |
| evolutionaryOrigin | derived from ancestral Sm proteins ⓘ |
| formsComplex |
LSm1–7 complex
NERFINISHED
ⓘ
LSm2–8 complex NERFINISHED ⓘ heptameric ring ⓘ heteroheptameric complex ⓘ |
| formsComplexWith |
U6 snRNA
NERFINISHED
ⓘ
mRNA decay factors ⓘ other Sm/LSm proteins ⓘ pre-mRNA ⓘ |
| foundIn |
archaea
ⓘ
eukaryotic cells ⓘ |
| geneFamilyMembers |
LSM1
NERFINISHED
ⓘ
LSM2 NERFINISHED ⓘ LSM3 ⓘ LSM4 NERFINISHED ⓘ LSM5 ⓘ LSM6 NERFINISHED ⓘ LSM7 ⓘ LSM8 NERFINISHED ⓘ |
| hasCharacteristic |
RNA-binding
ⓘ
eukaryote-wide distribution ⓘ highly conserved ⓘ oligomeric ⓘ ring-shaped complex-forming ⓘ |
| localization |
P-bodies
ⓘ
U6 snRNP NERFINISHED ⓘ cytoplasm ⓘ nucleus ⓘ spliceosome ⓘ |
| participatesIn |
RNA metabolism
ⓘ
RNA quality control ⓘ U6 snRNP assembly ⓘ mRNA decay ⓘ mRNA processing ⓘ mRNA stabilization ⓘ pre-mRNA splicing ⓘ spliceosome assembly ⓘ translation regulation ⓘ |
| sharesHomologyWith | canonical Sm proteins ⓘ |
| subClassOf | Sm-like proteins NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Survival motor neuron protein