Gemin8
E561089
Gemin8 is a component of the SMN (survival motor neuron) complex involved in the assembly and maturation of small nuclear ribonucleoproteins (snRNPs) essential for pre-mRNA splicing.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| Gemin7 | 1 |
Statements (25)
| Predicate | Object |
|---|---|
| instanceOf |
SMN complex component
ⓘ
protein ⓘ |
| associatedWith |
SMN complex
ⓘ
survival motor neuron (SMN) protein ⓘ |
| associatedWithComplex | Gemin6–Gemin7–Gemin8 subcomplex NERFINISHED ⓘ |
| associatedWithDisease | spinal muscular atrophy (via SMN complex dysfunction) ⓘ |
| associatedWithProcess |
RNA processing
ⓘ
spliceosomal snRNP biogenesis ⓘ |
| binds |
Gemin6
NERFINISHED
ⓘ
Gemin7 NERFINISHED ⓘ SMN protein NERFINISHED ⓘ |
| cellularComponent |
Cajal bodies
NERFINISHED
ⓘ
nuclear gem (Gemini of coiled bodies) ⓘ |
| fullName | gem-associated protein 8 NERFINISHED ⓘ |
| geneName | GEMIN8 ⓘ |
| involvedIn |
assembly of small nuclear ribonucleoproteins
ⓘ
maturation of small nuclear ribonucleoproteins ⓘ pre-mRNA splicing ⓘ |
| locatedIn |
cytoplasm
ⓘ
nucleus ⓘ |
| molecularFunction |
RNA-binding complex assembly factor
ⓘ
protein binding ⓘ |
| organism | Homo sapiens NERFINISHED ⓘ |
| partOf | SMN complex NERFINISHED ⓘ |
| requiredFor | efficient snRNP assembly ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Survival motor neuron protein
this entity surface form:
Gemin7
subject surface form:
Survival motor neuron protein