CYP1A2

E561029
cytochrome P450 enzyme drug-metabolizing enzyme protein

CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.

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Statements (50)

Predicate Object
instanceOf cytochrome P450 enzyme ⓘ
drug-metabolizing enzyme ⓘ
protein ⓘ
affects clearance of caffeine ⓘ
clearance of clozapine ⓘ
clearance of theophylline ⓘ
biologicalProcess drug metabolism ⓘ
oxidation-reduction process ⓘ
xenobiotic metabolic process ⓘ
chromosomalLocation 15q24.1 ⓘ
encodes cytochrome P450 1A2 protein ⓘ
expressedIn liver ⓘ
gene CYP1A2 NERFINISHED ⓘ
hasMolecularFunction monooxygenase activity ⓘ
oxidoreductase activity ⓘ
inducedBy cruciferous vegetables ⓘ
omeprazole ⓘ
polycyclic aromatic hydrocarbons ⓘ
smoking ⓘ
inhibitedBy cimetidine ⓘ
ciprofloxacin ⓘ
enoxacin ⓘ
fluoroquinolone antibiotics ⓘ
fluvoxamine ⓘ
oral contraceptives ⓘ
locatedIn endoplasmic reticulum membrane ⓘ
memberOf CYP1 family NERFINISHED ⓘ
CYP1A subfamily NERFINISHED ⓘ
cytochrome P450 superfamily NERFINISHED ⓘ
organism Homo sapiens ⓘ
polymorphismAssociatedWith risk of adverse drug reactions ⓘ
variation in caffeine metabolism ⓘ
variation in drug response ⓘ
regulatedBy aryl hydrocarbon receptor ⓘ
substrateOf aflatoxin B1 ⓘ
amitriptyline NERFINISHED ⓘ
caffeine ⓘ
clozapine NERFINISHED ⓘ
duloxetine ⓘ
imipramine NERFINISHED ⓘ
olanzapine ⓘ
phenacetin ⓘ
polycyclic aromatic hydrocarbons ⓘ
rasagiline ⓘ
tacrine ⓘ
theophylline NERFINISHED ⓘ
tizanidine ⓘ
warfarin ⓘ
usesCofactor NADPH ⓘ
heme ⓘ

Referenced by (3)

Full triples — surface form annotated when it differs from this entity's canonical label.

Cymbalta → isMetabolizedBy → CYP1A2 ⓘ
riluzole → isMetabolizedBy → CYP1A2 ⓘ
subject surface form: Riluzole
warfarin → metabolizedBy → CYP1A2 ⓘ