CYP2D6
E559472
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
Statements (64)
| Predicate | Object |
|---|---|
| instanceOf |
cytochrome P450 enzyme
ⓘ
drug-metabolizing enzyme ⓘ gene ⓘ |
| associatedWith |
adverse drug reactions to CYP2D6 substrates
ⓘ
breast cancer treatment outcome with tamoxifen ⓘ treatment failure with certain antidepressants ⓘ variable analgesic response to codeine ⓘ |
| belongsToFamily | cytochrome P450 family 2 ⓘ |
| belongsToSubfamily | cytochrome P450 subfamily D ⓘ |
| biologicalProcess |
drug metabolic process
ⓘ
oxidation-reduction process ⓘ xenobiotic metabolic process ⓘ |
| cellularComponent | endoplasmic reticulum membrane ⓘ |
| clinicalRelevance |
dose adjustment of CYP2D6 substrates
ⓘ
personalized medicine ⓘ pharmacogenomics ⓘ |
| cofactor |
NADPH
ⓘ
molecular oxygen ⓘ |
| encodes | cytochrome P450 2D6 protein ⓘ |
| enzymeCommissionNumber | EC 1.14.14.1 ⓘ |
| expressedIn |
brain
ⓘ
liver ⓘ small intestine ⓘ |
| fullName | cytochrome P450 family 2 subfamily D member 6 NERFINISHED ⓘ |
| geneFamily | CYP2D gene cluster NERFINISHED ⓘ |
| hasAllele |
CYP2D6*1
NERFINISHED
ⓘ
CYP2D6*10 NERFINISHED ⓘ CYP2D6*17 NERFINISHED ⓘ CYP2D6*2 ⓘ CYP2D6*3 NERFINISHED ⓘ CYP2D6*4 NERFINISHED ⓘ CYP2D6*41 NERFINISHED ⓘ CYP2D6*5 NERFINISHED ⓘ |
| hasPhenotype |
extensive metabolizer
ⓘ
intermediate metabolizer ⓘ poor metabolizer ⓘ ultrarapid metabolizer ⓘ |
| highlyPolymorphic | true ⓘ |
| locatedIn | endoplasmic reticulum ⓘ |
| locatedOnChromosome | chromosome 22q13.2 ⓘ |
| metabolizes |
antiarrhythmics
ⓘ
antidepressants ⓘ antipsychotics ⓘ beta blockers ⓘ codeine NERFINISHED ⓘ debrisoquine ⓘ dextromethorphan NERFINISHED ⓘ metoprolol ⓘ opioid analgesics ⓘ tamoxifen ⓘ tramadol ⓘ |
| molecularFunction |
monooxygenase activity
ⓘ
oxidoreductase activity ⓘ |
| orthologIn |
Mus musculus
NERFINISHED
ⓘ
Rattus norvegicus NERFINISHED ⓘ |
| pathway |
drug metabolism via cytochrome P450
ⓘ
phase I xenobiotic metabolism ⓘ |
| polymorphismConsequence |
interindividual variability in drug response
ⓘ
variable drug clearance ⓘ variable drug efficacy ⓘ variable risk of adverse drug reactions ⓘ |
| species | Homo sapiens ⓘ |
| substrateType |
clinically used drugs
ⓘ
xenobiotics ⓘ |
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.