University of Toronto insulin research team
E548073
The University of Toronto insulin research team was the pioneering group of scientists in the early 1920s that first isolated and developed insulin as a treatment for diabetes.
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
historical scientific collaboration
ⓘ
scientific research team ⓘ |
| activeInPeriod | early 1920s ⓘ |
| affiliation | University of Toronto NERFINISHED ⓘ |
| associatedAward | 1923 Nobel Prize in Physiology or Medicine NERFINISHED ⓘ |
| associatedWithNobelLaureate |
Frederick Banting
NERFINISHED
ⓘ
John James Rickard Macleod NERFINISHED ⓘ |
| biochemist | James Bertram Collip NERFINISHED ⓘ |
| collaborationWith | Connaught Laboratories NERFINISHED ⓘ |
| country | Canada ⓘ |
| developed |
methods for extraction and purification of insulin from animal pancreases
ⓘ
therapeutic insulin preparation for human use ⓘ |
| field |
biochemistry
ⓘ
diabetology ⓘ endocrinology ⓘ medicine ⓘ |
| firstHumanPatient | Leonard Thompson NERFINISHED ⓘ |
| impact |
enabled large-scale production of insulin
ⓘ
transformed diabetes from a rapidly fatal disease to a manageable chronic condition ⓘ |
| institutionalSupportFrom | University of Toronto Faculty of Medicine NERFINISHED ⓘ |
| leadScientist | Frederick Banting NERFINISHED ⓘ |
| legacy |
foundation for modern insulin therapy worldwide
ⓘ
major milestone in the history of endocrinology ⓘ |
| location |
Canada
NERFINISHED
ⓘ
Ontario NERFINISHED ⓘ Toronto ⓘ |
| member |
Charles Best
NERFINISHED
ⓘ
Frederick Banting NERFINISHED ⓘ James Bertram Collip NERFINISHED ⓘ John James Rickard Macleod NERFINISHED ⓘ |
| notableFor |
development of insulin as a treatment for diabetes
ⓘ
first successful isolation of insulin for therapeutic use ⓘ pioneering work in hormone extraction and purification ⓘ |
| researchFocus |
isolation of internal pancreatic secretion
ⓘ
pancreatic extracts ⓘ treatment of diabetes mellitus ⓘ |
| scientificContribution |
demonstration that pancreatic extracts could lower blood glucose levels
ⓘ
establishment of dosage and administration protocols for insulin therapy ⓘ isolation of the active antidiabetic principle later named insulin ⓘ |
| studentResearcher | Charles Best NERFINISHED ⓘ |
| supervisingProfessor | John James Rickard Macleod NERFINISHED ⓘ |
| testedOn | dogs with experimentally induced diabetes ⓘ |
| timePeriodOfFirstClinicalUse | 1922 ⓘ |
| timePeriodOfKeyDiscovery | 1921 ⓘ |
| usedMaterial | pancreatic tissue from animals ⓘ |
| usedSpecies |
cattle
ⓘ
dogs ⓘ pigs ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.