Fentanyl
E490748
Fentanyl is a powerful synthetic opioid analgesic, much stronger than morphine, used medically for severe pain but also widely associated with overdose deaths in the illicit drug market.
Statements (77)
| Predicate | Object |
|---|---|
| instanceOf |
narcotic analgesic
ⓘ
opioid ⓘ phenylpiperidine ⓘ synthetic opioid analgesic ⓘ |
| actsOnReceptor | mu-opioid receptor NERFINISHED ⓘ |
| antidote | naloxone ⓘ |
| associatedWith |
illicit drug market
ⓘ
opioid overdose epidemic in North America ⓘ |
| ATCCode | N01AH01 ⓘ |
| CASNumber | 437-38-7 ⓘ |
| chemicalFormula | C22H28N2O ⓘ |
| contraindication |
acute severe asthma
ⓘ
significant respiratory depression ⓘ |
| countryOfOrigin | Belgium NERFINISHED ⓘ |
| developedBy |
Janssen Pharmaceutica
NERFINISHED
ⓘ
Paul Janssen NERFINISHED ⓘ |
| durationOfActionIV | 30 to 60 minutes ⓘ |
| excretedBy | kidneys ⓘ |
| halfLife | about 3 to 12 hours depending on formulation ⓘ |
| hasAnalog |
alfentanil
NERFINISHED
ⓘ
carfentanil ⓘ remifentanil NERFINISHED ⓘ sufentanil NERFINISHED ⓘ |
| hasIUPACName | N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide ⓘ |
| illicitForm |
adulterant in counterfeit prescription pills
ⓘ
adulterant in heroin ⓘ counterfeit tablets ⓘ powder ⓘ |
| introducedMedicallyIn | 1960s ⓘ |
| legalStatus |
Schedule II controlled substance in the United States
ⓘ
controlled drug under the Misuse of Drugs Act in the United Kingdom ⓘ controlled substance in Canada ⓘ |
| mechanismOfAction | mu-opioid receptor agonist ⓘ |
| medicalUse |
anesthesia adjunct
ⓘ
management of breakthrough cancer pain ⓘ |
| metabolizedBy | CYP3A4 ⓘ |
| molarMass | 336.47 g/mol ⓘ |
| onsetOfActionIV | within minutes ⓘ |
| overdoseSymptom |
loss of consciousness
ⓘ
pinpoint pupils ⓘ severe respiratory depression ⓘ |
| pharmaceuticalForm |
buccal tablet
ⓘ
injectable solution ⓘ lozenge ⓘ nasal spray ⓘ transdermal patch ⓘ |
| pregnancyCategoryUS | varies by formulation, generally Category C ⓘ |
| primaryMedicalUse | treatment of severe pain ⓘ |
| primaryMetabolite | norfentanyl ⓘ |
| relativePotencyToHeroin | about 30 to 50 times more potent than heroin ⓘ |
| relativePotencyToMorphine | about 50 to 100 times more potent than morphine ⓘ |
| risk |
life-threatening respiratory depression
ⓘ
opioid use disorder ⓘ overdose ⓘ physical dependence ⓘ |
| riskGroup | high risk of fatal overdose in opioid-naive individuals ⓘ |
| routeOfAdministration |
buccal
ⓘ
intramuscular ⓘ intranasal ⓘ intravenous ⓘ sublingual ⓘ transdermal ⓘ |
| sideEffect |
bradycardia
ⓘ
constipation ⓘ nausea ⓘ respiratory depression ⓘ sedation ⓘ |
| solubility | highly lipophilic ⓘ |
| streetName |
Apache
NERFINISHED
ⓘ
China White ⓘ Dance Fever NERFINISHED ⓘ Friend ⓘ Goodfella NERFINISHED ⓘ |
| UNDrugControl | listed in Schedule I of the Single Convention on Narcotic Drugs ⓘ |
| usedIn |
intensive care unit sedation
ⓘ
perioperative anesthesia ⓘ |
| yearOfDiscovery | 1960 ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.