Zoloft
E474931
Zoloft is a widely prescribed antidepressant medication (sertraline) in the selective serotonin reuptake inhibitor (SSRI) class, commonly used to treat depression, anxiety disorders, and related conditions.
Statements (57)
| Predicate | Object |
|---|---|
| instanceOf |
antidepressant
ⓘ
brand name ⓘ pharmaceutical drug ⓘ selective serotonin reuptake inhibitor ⓘ |
| affects | serotonin reuptake ⓘ |
| hasATCCode | N06AB06 NERFINISHED ⓘ |
| hasBlackBoxWarning | increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults ⓘ |
| hasCommonSideEffect |
decreased libido
ⓘ
diarrhea ⓘ dry mouth ⓘ ejaculatory delay ⓘ headache ⓘ insomnia ⓘ nausea ⓘ sexual dysfunction ⓘ somnolence ⓘ |
| hasCommonStartingDose_mgPerDay |
25
ⓘ
50 ⓘ |
| hasDosageForm |
oral concentrate
ⓘ
tablet ⓘ |
| hasDrugClass | SSRI NERFINISHED ⓘ |
| hasEliminationHalfLife_hours | 26 ⓘ |
| hasFDAApprovalYear | 1991 ⓘ |
| hasFullEffectTime_weeks | 4–6 ⓘ |
| hasGenericName | sertraline NERFINISHED ⓘ |
| hasLegalStatus_UK | POM ⓘ |
| hasLegalStatus_US | Rx-only ⓘ |
| hasMaximumTypicalDose_mgPerDay | 200 ⓘ |
| hasMechanismOfAction | inhibition of serotonin transporter ⓘ |
| hasOnsetOfAction_weeks | 1–2 ⓘ |
| hasPregnancyCategory_US | C ⓘ |
| hasProteinBinding_percent | 98 ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| hasSeriousAdverseEffect |
QT prolongation
ⓘ
hyponatremia ⓘ serotonin syndrome ⓘ suicidal ideation ⓘ |
| isAdministeredOnce | daily ⓘ |
| isContraindicatedWith |
MAO inhibitors
ⓘ
pimozide ⓘ |
| isManufacturedBy | Pfizer NERFINISHED ⓘ |
| isMetabolizedBy |
CYP2B6
NERFINISHED
ⓘ
CYP2C19 NERFINISHED ⓘ CYP2D6 NERFINISHED ⓘ CYP3A4 NERFINISHED ⓘ |
| isPrescriptionStatus_EU | prescription only ⓘ |
| isPrescriptionStatus_US | prescription only ⓘ |
| isTakenWithOrWithout | food ⓘ |
| isUsedFor |
generalized anxiety disorder
ⓘ
major depressive disorder ⓘ obsessive-compulsive disorder ⓘ panic disorder ⓘ post-traumatic stress disorder ⓘ premenstrual dysphoric disorder ⓘ social anxiety disorder ⓘ |
| tradeNameOf | sertraline NERFINISHED ⓘ |
| wasApprovedBy | U.S. Food and Drug Administration NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.