Singulair
E468961
Singulair is a prescription leukotriene receptor antagonist (montelukast) commonly used to prevent and manage asthma and allergy symptoms.
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
brand name drug
ⓘ
pharmaceutical drug ⓘ |
| actsOn | cysteinyl leukotriene receptor CysLT1 NERFINISHED ⓘ |
| boxedWarning | risk of serious neuropsychiatric events ⓘ |
| brandNameOf | montelukast ⓘ |
| commonSideEffect |
abdominal pain
ⓘ
cough ⓘ headache ⓘ upper respiratory infection ⓘ |
| contraindication | hypersensitivity to montelukast ⓘ |
| dosageForm |
chewable tablet
ⓘ
film-coated tablet ⓘ oral granules ⓘ |
| dosingFrequency | once daily ⓘ |
| drugClass |
anti-asthmatic agent
ⓘ
leukotriene receptor antagonist ⓘ respiratory system drug ⓘ |
| eliminationRoute | biliary excretion ⓘ |
| firstApprovalRegion | United States NERFINISHED ⓘ |
| hasActiveIngredient | montelukast sodium ⓘ |
| hasATCCode | R03DC03 ⓘ |
| hasBlackBoxWarningRegion | United States NERFINISHED ⓘ |
| hasGenericName | montelukast ⓘ |
| indication |
asthma prophylaxis
ⓘ
chronic asthma management ⓘ exercise-induced bronchoconstriction prevention ⓘ perennial allergic rhinitis ⓘ seasonal allergic rhinitis ⓘ |
| lactationUse | caution advised ⓘ |
| marketingAuthorizationHolder | Merck & Co. NERFINISHED ⓘ |
| mechanismOfAction |
inhibits leukotriene-mediated bronchoconstriction
ⓘ
reduces airway inflammation ⓘ selective leukotriene receptor antagonist ⓘ |
| metabolism | hepatic ⓘ |
| metabolizingEnzyme |
CYP2C9
NERFINISHED
ⓘ
CYP3A4 NERFINISHED ⓘ |
| notForUse | acute asthma attacks relief ⓘ |
| onsetOfAction | within hours ⓘ |
| pregnancyCategory | data suggest low risk but use if clearly needed ⓘ |
| regulatoryStatus | prescription only ⓘ |
| routeOfAdministration | oral ⓘ |
| seriousSideEffect |
agitation
ⓘ
depression ⓘ neuropsychiatric events ⓘ suicidal thoughts ⓘ |
| targetPopulation |
adults with asthma
ⓘ
children with asthma ⓘ patients with allergic rhinitis ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.