Isentress
E468958
HIV integrase inhibitor
antiretroviral medication
brand name drug
high-dose formulation of Isentress
Isentress is an antiretroviral medication (an HIV integrase inhibitor) used to treat HIV infection in adults and children.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| Isentress HD | 0 |
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
HIV integrase inhibitor
ⓘ
antiretroviral medication ⓘ brand name drug ⓘ high-dose formulation of Isentress ⓘ |
| alsoKnownAs | raltegravir NERFINISHED ⓘ |
| approvalYear | 2007 ⓘ |
| approvedBy | U.S. Food and Drug Administration NERFINISHED ⓘ |
| ATCCode | J05AX08 ⓘ |
| canCauseAdverseEffect |
depression
ⓘ
elevated liver enzymes ⓘ fatigue ⓘ headache ⓘ insomnia ⓘ nausea ⓘ rash ⓘ suicidal ideation ⓘ |
| developedBy | Merck & Co. NERFINISHED ⓘ |
| dosageForm |
chewable tablet
ⓘ
film-coated tablet ⓘ oral suspension ⓘ tablet ⓘ |
| eliminationRoute |
feces
ⓘ
urine ⓘ |
| hasActiveIngredient | raltegravir NERFINISHED ⓘ |
| hasBlackBoxWarning | no ⓘ |
| hasBrandOwner | Merck Sharp & Dohme Corp. NERFINISHED ⓘ |
| hasContraindication | known hypersensitivity to raltegravir ⓘ |
| hasDrugClass | integrase strand transfer inhibitor ⓘ |
| hasHalfLife | approximately 9 hours ⓘ |
| indicatedFor |
treatment-experienced HIV patients
ⓘ
treatment-naive HIV patients ⓘ use in combination with other antiretroviral agents ⓘ |
| isAvailableAs | Isentress HD NERFINISHED ⓘ |
| isFirstInClass | yes ⓘ |
| isPartOfTherapy | combination antiretroviral therapy ⓘ |
| legalStatusEU | prescription only ⓘ |
| legalStatusUS | prescription only ⓘ |
| mechanismOfAction |
inhibits HIV integrase enzyme
ⓘ
prevents integration of viral DNA into host genome ⓘ |
| metabolism | primarily by UGT1A1-mediated glucuronidation ⓘ |
| pregnancyCategoryUS | C ⓘ |
| routeOfAdministration | oral ⓘ |
| target | HIV-1 integrase NERFINISHED ⓘ |
| treats |
HIV infection
ⓘ
HIV-1 infection ⓘ |
| usedIn |
adult patients
ⓘ
pediatric patients ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.