PR3-ANCA
E465982
PR3-ANCA is an autoantibody directed against proteinase 3 that is strongly associated with granulomatosis with polyangiitis (formerly Wegener's granulomatosis) and used as a key diagnostic marker for this vasculitic disease.
Statements (46)
| Predicate | Object |
|---|---|
| instanceOf | autoantibody ⓘ |
| abbreviationOf | proteinase 3 antineutrophil cytoplasmic antibody ⓘ |
| antibodyClass | IgG ⓘ |
| antigenLocation |
azurophilic granules of neutrophils
ⓘ
monocyte lysosomes ⓘ |
| antigenType | serine protease ⓘ |
| associatedWithAntigen | PR3 ⓘ |
| associatedWithClinicalFeature |
necrotizing granulomatous inflammation
ⓘ
necrotizing vasculitis of small to medium vessels ⓘ |
| associatedWithDisease |
ANCA-associated vasculitis
ⓘ
Wegener's granulomatosis NERFINISHED ⓘ granulomatosis with polyangiitis NERFINISHED ⓘ systemic small-vessel vasculitis ⓘ |
| associatedWithOrganInvolvement |
kidneys
ⓘ
lower respiratory tract ⓘ upper respiratory tract ⓘ |
| associatedWithPrognosis | relapse risk in ANCA-associated vasculitis ⓘ |
| belongsToField |
clinical immunology
ⓘ
nephrology ⓘ rheumatology ⓘ |
| biologicalRole | pathogenic autoantibody in some models of vasculitis ⓘ |
| clinicalRelevance |
high specificity for granulomatosis with polyangiitis
ⓘ
supports diagnosis in compatible clinical context ⓘ |
| contrastedWith | MPO-ANCA ⓘ |
| detectedBy |
enzyme-linked immunosorbent assay
ⓘ
indirect immunofluorescence ⓘ |
| fullName | proteinase 3 antineutrophil cytoplasmic antibody ⓘ |
| hasAlternativeName | c-ANCA to proteinase 3 ⓘ |
| hasHigherPrevalenceIn | granulomatosis with polyangiitis compared to microscopic polyangiitis ⓘ |
| hasImmunofluorescencePattern |
c-ANCA
ⓘ
cytoplasmic ANCA pattern ⓘ |
| isSubtypeOf |
ANCA
ⓘ
antineutrophil cytoplasmic antibody ⓘ |
| laboratoryTestType | autoantibody test ⓘ |
| measuredIn |
plasma
ⓘ
serum ⓘ |
| standardizedIn | international ANCA testing guidelines ⓘ |
| targetAntigen | proteinase 3 ⓘ |
| targetLocation | neutrophil cytoplasmic granules ⓘ |
| usedAs |
diagnostic marker
ⓘ
serologic marker ⓘ |
| usedFor |
disease classification in vasculitis
ⓘ
monitoring disease activity in some patients ⓘ |
| usedIn | classification criteria for ANCA-associated vasculitis ⓘ |
| usedInDiagnosisOf |
ANCA-associated vasculitis
ⓘ
granulomatosis with polyangiitis ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.