GPA
E465980
GPA is an autoimmune form of vasculitis that causes inflammation of small- and medium-sized blood vessels, particularly affecting the respiratory tract and kidneys.
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
autoimmune disease
ⓘ
medium-vessel vasculitis ⓘ small-vessel vasculitis ⓘ vasculitis ⓘ |
| affectsAnatomicalStructure |
medium-sized blood vessels
ⓘ
small blood vessels ⓘ |
| affectsOrgan |
kidneys
ⓘ
lungs ⓘ |
| affectsSystem | respiratory tract ⓘ |
| associatedWithAntibody |
PR3-ANCA
ⓘ
c-ANCA ⓘ |
| formerlyKnownAs | Wegener's granulomatosis NERFINISHED ⓘ |
| fullName | Granulomatosis with polyangiitis NERFINISHED ⓘ |
| hasClassification | ANCA-associated vasculitis ⓘ |
| hasComplication |
chronic kidney disease
ⓘ
hearing loss ⓘ pulmonary hemorrhage ⓘ rapidly progressive glomerulonephritis ⓘ subglottic stenosis ⓘ |
| hasCourse | chronic relapsing ⓘ |
| hasDiagnosticTest |
ANCA testing
ⓘ
chest CT scan ⓘ kidney biopsy ⓘ nasal or sinus biopsy ⓘ |
| hasEpidemiology | rare disease ⓘ |
| hasEtiology | autoimmune mechanism ⓘ |
| hasOnset | insidious ⓘ |
| hasPathologicalProcess |
granulomatous inflammation
ⓘ
necrotizing vasculitis ⓘ |
| hasSexPredominance | slight male predominance ⓘ |
| hasSymptom |
arthralgia
ⓘ
chronic sinusitis ⓘ cough ⓘ dyspnea ⓘ epistaxis ⓘ fatigue ⓘ fever ⓘ hemoptysis ⓘ nasal congestion ⓘ otitis media ⓘ weight loss ⓘ |
| includedIn | Chapel Hill Consensus Conference vasculitis nomenclature NERFINISHED ⓘ |
| recognizedBy | American College of Rheumatology classification criteria ⓘ |
| treatedWith |
azathioprine
ⓘ
cyclophosphamide ⓘ glucocorticoids ⓘ methotrexate ⓘ mycophenolate mofetil NERFINISHED ⓘ rituximab NERFINISHED ⓘ |
| typicalAgeOfOnset | middle adulthood ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.