influenza virus neuraminidase
E414768
Influenza virus neuraminidase is a surface enzyme on influenza viruses that enables the release and spread of new viral particles from infected cells and is a key target of antiviral drugs.
All labels observed (1)
| Label | Occurrences |
|---|---|
| influenza virus neuraminidase canonical | 1 |
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
drug target
ⓘ
enzyme ⓘ sialidase ⓘ viral surface glycoprotein ⓘ |
| antigenicSubtype |
N1
ⓘ
N2 ⓘ N3 ⓘ N4 ⓘ N5 ⓘ N6 ⓘ N7 ⓘ N8 ⓘ N9 ⓘ |
| biologicalProcess |
cleavage of sialic acid from host cell surface receptors
ⓘ
prevention of virion aggregation ⓘ viral release from host cell ⓘ viral spread in respiratory epithelium ⓘ |
| catalyzes | hydrolysis of terminal sialic acid residues from glycoproteins and glycolipids ⓘ |
| cellularLocation |
viral envelope
ⓘ
virion surface ⓘ |
| encodedBy | influenza virus NA gene ⓘ |
| evolvesBy |
antigenic drift
ⓘ
reassortment of NA gene segment ⓘ |
| formsComplexWith | influenza virus hemagglutinin on virion surface ⓘ |
| foundInTaxon |
influenza A virus
ⓘ
influenza B virus ⓘ influenza C virus ⓘ |
| hasActiveSiteResidue |
arginine triad in catalytic site
ⓘ
tyrosine 406 (in N2 numbering) ⓘ |
| hasDomain |
globular head domain
ⓘ
stalk domain ⓘ |
| hasMolecularFunction |
exosialidase activity
ⓘ
glycosidase activity ⓘ |
| hasQuaternaryStructure | homotetramer ⓘ |
| hasStructure | six-bladed beta-propeller fold in globular head ⓘ |
| isAntigenOf |
influenza A virus N subtypes
ⓘ
influenza B virus neuraminidase antigen ⓘ |
| isComponentOf | influenza virus envelope protein coat ⓘ |
| isTargetOf |
laninamivir
ⓘ
neuraminidase inhibitor class antivirals ⓘ neutralizing antibodies ⓘ oseltamivir ⓘ peramivir ⓘ zanamivir ⓘ |
| postTranslationalModification | N-linked glycosylation ⓘ |
| roleInDisease | contributes to pathogenicity of influenza infection ⓘ |
| substrate |
neuraminic acid residues
ⓘ
sialic acid-containing receptors ⓘ |
| usedFor | subtyping of influenza A viruses ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.