click chemistry

E316989

chemical concept modular synthesis strategy synthetic methodology

Click chemistry is a modular, high-yielding approach to chemical synthesis that uses simple, reliable reactions to rapidly assemble complex molecules, widely applied in drug discovery, materials science, and chemical biology.

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All labels observed (2)

Label	Occurrences
click chemistry canonical	2
CuAAC	1

Statements (52)

Predicate	Object
instanceOf	chemical concept ⓘ modular synthesis strategy ⓘ synthetic methodology ⓘ
characteristic	fast reaction kinetics ⓘ high selectivity ⓘ high-yielding reactions ⓘ modular assembly of molecules ⓘ operational simplicity ⓘ orthogonality to many functional groups ⓘ produces inoffensive byproducts ⓘ reliability ⓘ tolerance of aqueous conditions ⓘ
coreReactionType	click chemistry self-linksurface differs ⓘ surface form: CuAAC Diels–Alder reaction ⓘ SPAAC ⓘ SuFEx ⓘ copper-catalyzed azide–alkyne cycloaddition ⓘ inverse electron-demand Diels–Alder reaction ⓘ strain-promoted azide–alkyne cycloaddition ⓘ sulfur(VI) fluoride exchange ⓘ thiol–ene reaction ⓘ thiol–yne reaction ⓘ
criterion	high thermodynamic driving force ⓘ insensitivity to oxygen and water when possible ⓘ simple product isolation ⓘ use of readily available starting materials ⓘ
definedBy	Hartmuth C. Kolb NERFINISHED ⓘ K. Barry Sharpless ⓘ M. G. Finn ⓘ
enables	bioorthogonal labeling in living systems ⓘ
fieldOfApplication	bioconjugation ⓘ chemical biology ⓘ drug discovery ⓘ materials science ⓘ medicinal chemistry ⓘ nanotechnology ⓘ polymer chemistry ⓘ
goal	rapid assembly of complex molecules ⓘ streamlining chemical synthesis ⓘ
hasSubfield	bioorthogonal click chemistry ⓘ
introducedInPublication	Angewandte Chemie ⓘ surface form: Angewandte Chemie International Edition
introducedInYear	2001 ⓘ
recognizedBy	Royal Swedish Academy of Sciences ⓘ
relatedAward	Nobel Prize in Chemistry ⓘ surface form: 2022 Nobel Prize in Chemistry
usedFor	antibody–drug conjugate construction ⓘ biomolecule labeling ⓘ combinatorial library synthesis ⓘ fragment-based drug design ⓘ in vivo imaging ⓘ polymer functionalization ⓘ surface modification ⓘ target identification in chemical biology ⓘ

Referenced by (3)

Full triples — surface form annotated when it differs from this entity's canonical label.

K. Barry Sharpless → notableWork → click chemistry ⓘ

click chemistry → coreReactionType → click chemistry self-linksurface differs ⓘ

this entity surface form: CuAAC

Morten Meldal → knownFor → click chemistry ⓘ