THCA (tetrahydrocannabinolic acid)
E275976
THCA (tetrahydrocannabinolic acid) is the non-psychoactive acidic precursor to THC found in raw cannabis, which converts into psychoactive THC through decarboxylation (heat or aging).
All labels observed (1)
| Label | Occurrences |
|---|---|
| THCA (tetrahydrocannabinolic acid) canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2523409 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: THCA (tetrahydrocannabinolic acid) Context triple: [THC, biosynthesizedFrom, THCA (tetrahydrocannabinolic acid)]
-
A.
THC
THC (tetrahydrocannabinol) is the primary psychoactive compound in cannabis responsible for the plant’s mind-altering effects.
-
B.
CBD
CBD is an international treaty adopted in 1992 that aims to conserve biological diversity, promote sustainable use of its components, and ensure fair and equitable sharing of benefits arising from genetic resources.
-
C.
CBD
CBD is a non-intoxicating compound found in cannabis that is widely used for its potential therapeutic effects, such as reducing anxiety, pain, and inflammation.
-
D.
CBG
CBG is the National Rail station code for Cambridge railway station in Cambridge, England.
-
E.
Ganja
Ganja is one of Azerbaijan’s largest and oldest cities, known as a historic cultural and economic center in the South Caucasus.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: THCA (tetrahydrocannabinolic acid) Target entity description: THCA (tetrahydrocannabinolic acid) is the non-psychoactive acidic precursor to THC found in raw cannabis, which converts into psychoactive THC through decarboxylation (heat or aging).
-
A.
THC
THC (tetrahydrocannabinol) is the primary psychoactive compound in cannabis responsible for the plant’s mind-altering effects.
-
B.
CBD
CBD is an international treaty adopted in 1992 that aims to conserve biological diversity, promote sustainable use of its components, and ensure fair and equitable sharing of benefits arising from genetic resources.
-
C.
CBD
CBD is a non-intoxicating compound found in cannabis that is widely used for its potential therapeutic effects, such as reducing anxiety, pain, and inflammation.
-
D.
CBG
CBG is the National Rail station code for Cambridge railway station in Cambridge, England.
-
E.
Ganja
Ganja is one of Azerbaijan’s largest and oldest cities, known as a historic cultural and economic center in the South Caucasus.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
carboxylic acid
ⓘ
organic compound ⓘ phytocannabinoid ⓘ tetrahydrocannabinol derivative ⓘ |
| biosynthesisEnzyme | THCA synthase ⓘ |
| biosynthesizedFrom | CBGA ⓘ |
| chemicalClass |
cannabinoid acid
ⓘ
phenolic compound ⓘ |
| contributesTo | total potential THC content in cannabis ⓘ |
| conversionProcess | decarboxylation ⓘ |
| conversionTrigger |
aging
ⓘ
heat ⓘ light exposure ⓘ storage over time ⓘ |
| convertsTo | THC ⓘ |
| decarboxylationProduct | carbon dioxide ⓘ |
| existsPrimarilyAs | acidic form before heating or curing ⓘ |
| foundIn |
Cannabis
ⓘ
surface form:
Cannabis indica
Cannabis ⓘ
surface form:
Cannabis sativa
raw cannabis ⓘ |
| fullName | tetrahydrocannabinolic acid ⓘ |
| hasFunctionalGroup |
carboxyl group
ⓘ
phenolic hydroxyl group ⓘ |
| hasIsomer |
THCA-A
ⓘ
THCA-B ⓘ |
| hasPotentialEffect |
anti-inflammatory activity (preclinical evidence)
ⓘ
antiemetic activity (preclinical evidence) ⓘ neuroprotective activity (preclinical evidence) ⓘ |
| isNonPsychoactivePrecursorOf | THC ⓘ |
| isPrecursorOf | THC ⓘ |
| IUPACName | 2-[(1R,3R)-3,7-dimethyl-2,6-dioxo-4-pentyl-1-cyclohexen-1-yl]-5-pentylbenzene-1,3-diol ⓘ |
| laboratoryAnalysis |
can be distinguished from THC in cannabinoid profiling
ⓘ
can be quantified by HPLC ⓘ |
| legalStatusDependsOn | jurisdiction ⓘ |
| majorFormOfTHCIn | raw cannabis plant ⓘ |
| metabolism | can be partially decarboxylated in the body ⓘ |
| occursAs | acidic form of THC ⓘ |
| oftenRegulatedSimilarlyTo | THC ⓘ |
| presentIn |
fresh cannabis flowers
ⓘ
fresh cannabis leaves ⓘ |
| psychoactivity | non-psychoactive ⓘ |
| regulatoryMeasurement | often included in total THC calculations ⓘ |
| routeOfAdministration |
ingestion of raw cannabis
ⓘ
topical application in some preparations ⓘ |
| solubility |
lipid-soluble
ⓘ
poorly water-soluble ⓘ |
| stability | thermally unstable ⓘ |
| usedIn | cannabis chemovar characterization ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: THCA (tetrahydrocannabinolic acid) Description of subject: THCA (tetrahydrocannabinolic acid) is the non-psychoactive acidic precursor to THC found in raw cannabis, which converts into psychoactive THC through decarboxylation (heat or aging).
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.