CLARITY
E261424
CLARITY is a tissue-clearing technique that renders biological tissues transparent while preserving their molecular and structural integrity for high-resolution imaging and analysis.
All labels observed (1)
| Label | Occurrences |
|---|---|
| CLARITY canonical | 3 |
How this entity was disambiguated
This entity first appeared as the object of triple T2366473 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CLARITY Context triple: [CLARITY tissue-clearing method, acronym, CLARITY]
-
A.
Moments of Clarity
Moments of Clarity is a memoir by Christopher Kennedy Lawford that explores his struggles with addiction and his journey toward recovery and self-understanding.
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B.
LEAR
LEAR (Low Energy Antiproton Ring) was a CERN facility designed to store and decelerate antiprotons for precision experiments in antimatter physics.
-
C.
Clearing
Clearing is a residential and industrial neighborhood on the southwest side of Chicago, known for encompassing and surrounding Midway International Airport.
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D.
Light and Truth
Light and Truth is the English rendering of Yale University's Latin motto "Lux et Veritas," expressing the institution's commitment to knowledge and enlightenment.
-
E.
Lucid
Lucid is the surname of American biochemist and NASA astronaut Shannon Lucid, known for her long-duration spaceflights and record-setting time spent in orbit.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CLARITY Target entity description: CLARITY is a tissue-clearing technique that renders biological tissues transparent while preserving their molecular and structural integrity for high-resolution imaging and analysis.
-
A.
Moments of Clarity
Moments of Clarity is a memoir by Christopher Kennedy Lawford that explores his struggles with addiction and his journey toward recovery and self-understanding.
-
B.
LEAR
LEAR (Low Energy Antiproton Ring) was a CERN facility designed to store and decelerate antiprotons for precision experiments in antimatter physics.
-
C.
Clearing
Clearing is a residential and industrial neighborhood on the southwest side of Chicago, known for encompassing and surrounding Midway International Airport.
-
D.
Light and Truth
Light and Truth is the English rendering of Yale University's Latin motto "Lux et Veritas," expressing the institution's commitment to knowledge and enlightenment.
-
E.
Lucid
Lucid is the surname of American biochemist and NASA astronaut Shannon Lucid, known for her long-duration spaceflights and record-setting time spent in orbit.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
biological sample preparation method
ⓘ
tissue-clearing technique ⓘ |
| advantage |
allows imaging of large intact tissue volumes
ⓘ
maintains endogenous fluorescence ⓘ supports repeated rounds of staining and destaining ⓘ |
| appliedTo |
human brain tissue
ⓘ
other organs and tissues ⓘ rodent brain tissue ⓘ spinal cord tissue ⓘ |
| compatibleWith |
RNA in situ hybridization
ⓘ
antibody-based immunolabeling ⓘ fluorescent proteins ⓘ |
| developedAt | Stanford University ⓘ |
| developedBy |
Karl Deisseroth
ⓘ
Kwanghun Chung ⓘ |
| enables |
high-resolution three-dimensional imaging of intact tissues
ⓘ
in situ hybridization in cleared tissues ⓘ multiplexed immunostaining ⓘ whole-brain imaging ⓘ |
| field |
histology
ⓘ
neuroscience ⓘ optical imaging ⓘ |
| fullName |
CLARITY tissue-clearing method
ⓘ
surface form:
Clear Lipid-exchanged Acrylamide-hybridized Rigid Imaging/Immunostaining/In situ hybridization-compatible Tissue-hYdrogel
|
| hasVariant |
PACT
ⓘ
PARA ⓘ ePACT ⓘ passive CLARITY ⓘ |
| inspired | development of other tissue-clearing methods ⓘ |
| keyStep |
fixation of biomolecules to a hydrogel scaffold
ⓘ
refractive index matching ⓘ removal of light-scattering lipids ⓘ |
| limitation |
clearing time can be long for large tissues
ⓘ
requires optimization of antibody penetration ⓘ |
| preserves |
fine cellular morphology
ⓘ
nucleic acids in tissue ⓘ proteins in tissue ⓘ |
| primaryGoal |
preserve molecular integrity of tissues
ⓘ
preserve structural integrity of tissues ⓘ render biological tissues optically transparent ⓘ |
| publicationYear | 2013 ⓘ |
| publishedIn | Nature ⓘ |
| requires | specialized electrophoretic clearing chamber (in original protocol) ⓘ |
| usedFor |
mapping neural circuits
ⓘ
studying brain connectivity ⓘ visualizing pathological features in disease models ⓘ |
| uses |
acrylamide-based hydrogel matrix
ⓘ
electrophoretic tissue clearing ⓘ hydrogel embedding of tissue ⓘ lipid removal ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CLARITY Description of subject: CLARITY is a tissue-clearing technique that renders biological tissues transparent while preserving their molecular and structural integrity for high-resolution imaging and analysis.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.