Tegsedi
E133690
Tegsedi is an antisense oligonucleotide drug used to treat hereditary transthyretin-mediated amyloidosis by reducing the production of the transthyretin protein.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Tegsedi canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T1169603 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Tegsedi Context triple: [Ionis Pharmaceuticals, notableProduct, Tegsedi]
-
A.
Teda
Teda are a Saharan ethnic group, primarily inhabiting northern Chad and surrounding regions, known for their nomadic lifestyle and Tebu language.
-
B.
Tullistes
Tullistes are the inhabitants of the French city of Tulle, located in the Corrèze department in central France.
-
C.
Tuyo
"Tuyo" is a bolero-style song by Rodrigo Amarante, best known as the haunting opening theme of the television series *Narcos*.
-
D.
Takanot
Takanot are rabbinic enactments or decrees established to address communal needs and clarify or safeguard Jewish law within Rabbinic Judaism.
-
E.
Golus
Golus is a Yiddish term referring to the Jewish exile and dispersion from their ancestral homeland, encompassing both the physical diaspora and its spiritual-historical implications.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Tegsedi Target entity description: Tegsedi is an antisense oligonucleotide drug used to treat hereditary transthyretin-mediated amyloidosis by reducing the production of the transthyretin protein.
-
A.
Teda
Teda are a Saharan ethnic group, primarily inhabiting northern Chad and surrounding regions, known for their nomadic lifestyle and Tebu language.
-
B.
Tullistes
Tullistes are the inhabitants of the French city of Tulle, located in the Corrèze department in central France.
-
C.
Tuyo
"Tuyo" is a bolero-style song by Rodrigo Amarante, best known as the haunting opening theme of the television series *Narcos*.
-
D.
Takanot
Takanot are rabbinic enactments or decrees established to address communal needs and clarify or safeguard Jewish law within Rabbinic Judaism.
-
E.
Golus
Golus is a Yiddish term referring to the Jewish exile and dispersion from their ancestral homeland, encompassing both the physical diaspora and its spiritual-historical implications.
- F. None of above. chosen
Statements (45)
| Predicate | Object |
|---|---|
| instanceOf |
antisense oligonucleotide
ⓘ
pharmaceutical drug ⓘ transthyretin-directed therapy ⓘ |
| administeredTo | human patients ⓘ |
| approvalYear | 2018 ⓘ |
| approvedBy |
European Medicines Agency
ⓘ
Food and Drug Administration ⓘ
surface form:
U.S. Food and Drug Administration
|
| belongsTo |
Ionis Pharmaceuticals
ⓘ
surface form:
Ionis antisense pipeline
|
| blackBoxWarningFor |
glomerulonephritis
ⓘ
thrombocytopenia ⓘ |
| coDevelopedBy | Akcea Therapeutics ⓘ |
| commonAdverseEvent |
fatigue
ⓘ
headache ⓘ injection site reactions ⓘ nausea ⓘ |
| developedBy | Ionis Pharmaceuticals ⓘ |
| dosingFrequency | once weekly ⓘ |
| hasActiveIngredient | inotersen ⓘ |
| hasATCCode | N07XX11 ⓘ |
| hasDosageForm | solution for injection ⓘ |
| hasInternationalNonproprietaryName | inotersen ⓘ |
| indicatedFor | adults with hereditary transthyretin-mediated amyloidosis ⓘ |
| is | first-in-class antisense drug for hereditary transthyretin-mediated amyloidosis ⓘ |
| isAdministeredBy | healthcare professional or trained patient ⓘ |
| legalStatusInEuropeanUnion | prescription-only medicine ⓘ |
| legalStatusInUnitedStates | prescription-only medicine ⓘ |
| mechanismOfAction |
antisense-mediated degradation of TTR mRNA
ⓘ
transthyretin synthesis inhibition ⓘ |
| molecularTarget | TTR gene transcript ⓘ |
| pharmacologicalClass | antisense therapeutic ⓘ |
| reduces |
amyloid deposition progression
ⓘ
serum transthyretin levels ⓘ |
| reducesLevelOf | transthyretin protein ⓘ |
| reducesRiskOf | progression of polyneuropathy in hATTR patients ⓘ |
| regulatoryDesignation |
orphan drug in the United States
ⓘ
orphan medicinal product in the European Union ⓘ |
| requires |
regular platelet monitoring
ⓘ
renal function monitoring ⓘ |
| routeOfAdministration | subcutaneous injection ⓘ |
| targets | transthyretin mRNA ⓘ |
| therapyArea |
amyloidosis
ⓘ
neurology ⓘ rare diseases ⓘ |
| treats |
hereditary transthyretin-mediated amyloidosis
ⓘ
polyneuropathy of hereditary transthyretin-mediated amyloidosis ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Tegsedi Description of subject: Tegsedi is an antisense oligonucleotide drug used to treat hereditary transthyretin-mediated amyloidosis by reducing the production of the transthyretin protein.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.