GABA-A receptor
E1243368
UNEXPLORED
The GABA-A receptor is a ligand-gated chloride ion channel in the central nervous system that mediates fast inhibitory neurotransmission and is a primary target of many sedative, anxiolytic, and hypnotic drugs.
All labels observed (1)
| Label | Occurrences |
|---|---|
| GABA-A receptor canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T16952549 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: GABA-A receptor Context triple: [Ambien, actsOn, GABA-A receptor]
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A.
GABA
GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the mammalian central nervous system, crucial for reducing neuronal excitability and regulating muscle tone and anxiety.
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B.
NMDA receptor
The NMDA receptor is a glutamate-activated ion channel in the brain that plays a key role in synaptic plasticity, learning, and memory, and is implicated in various neurological and psychiatric disorders.
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C.
M2 muscarinic acetylcholine receptor
The M2 muscarinic acetylcholine receptor is a G protein–coupled receptor subtype primarily found in the heart, where it mediates parasympathetic (vagal) effects such as slowing heart rate and reducing contractility.
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D.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
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E.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: GABA-A receptor Target entity description: The GABA-A receptor is a ligand-gated chloride ion channel in the central nervous system that mediates fast inhibitory neurotransmission and is a primary target of many sedative, anxiolytic, and hypnotic drugs.
-
A.
GABA
GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the mammalian central nervous system, crucial for reducing neuronal excitability and regulating muscle tone and anxiety.
-
B.
NMDA receptor
The NMDA receptor is a glutamate-activated ion channel in the brain that plays a key role in synaptic plasticity, learning, and memory, and is implicated in various neurological and psychiatric disorders.
-
C.
M2 muscarinic acetylcholine receptor
The M2 muscarinic acetylcholine receptor is a G protein–coupled receptor subtype primarily found in the heart, where it mediates parasympathetic (vagal) effects such as slowing heart rate and reducing contractility.
-
D.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
E.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.