Triple
T34606093
| Position | Surface form | Disambiguated ID | Type / Status |
|---|---|---|---|
| Subject | acalabrutinib |
E888598
|
entity |
| Predicate | instanceOf |
P0
|
FINISHED |
| Object | second-generation BTK inhibitor |
C10036
|
CONCEPT FINISHED |
How this triple was built (1 step)
Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.
CD
Concept disambiguation
gpt-5-mini-2025-08-07
Target class: second-generation BTK inhibitor Context triple: [acalabrutinib, instanceOf, second-generation BTK inhibitor]
-
A.
Bruton tyrosine kinase inhibitor
chosen
A Bruton tyrosine kinase inhibitor is a targeted small-molecule drug that blocks BTK signaling in B cells to disrupt pathways critical for their activation, proliferation, and survival, primarily used in the treatment of certain B-cell malignancies and autoimmune diseases.
-
B.
Janus kinase inhibitor
A Janus kinase inhibitor is a drug that selectively blocks Janus kinase (JAK) enzymes to modulate cytokine signaling and reduce inflammation or abnormal immune activity in various diseases.
-
C.
tyrosine kinase inhibitor
A tyrosine kinase inhibitor is a drug that blocks the activity of tyrosine kinases—enzymes involved in cell signaling pathways—to prevent uncontrolled cell growth and proliferation, commonly used in cancer therapy.
-
D.
Bruton’s tyrosine kinase
Bruton’s tyrosine kinase is a non-receptor tyrosine kinase crucial for B-cell receptor signaling, development, and function, and is a key therapeutic target in certain autoimmune diseases and B-cell malignancies.
-
E.
CDK4/6 inhibitor
A CDK4/6 inhibitor is a targeted anticancer drug that blocks cyclin-dependent kinases 4 and 6 to halt cell cycle progression from G1 to S phase, thereby inhibiting tumor cell proliferation.
- F. None of above.
Provenance (1 batch)
The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.
| Step | Stage | Batch ID | Status | When |
|---|---|---|---|---|
| creating | Elicitation | batch_69f349d489d48190ba30e7d97c6f5ef9 |
completed | April 30, 2026, 12:23 p.m. |
Created at: May 1, 2026, 2:03 a.m.