Triple
T22796815
| Position | Surface form | Disambiguated ID | Type / Status |
|---|---|---|---|
| Subject | LOXO-195 |
E564270
|
entity |
| Predicate | predecessorDrug |
P149745
|
FINISHED |
| Object | larotrectinib |
—
|
NE NERFINISHED |
How this triple was built (3 steps)
Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.
NER
Named-entity recognition
gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: larotrectinib | Statement: [LOXO-195, predecessorDrug, larotrectinib]
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: larotrectinib Context triple: [LOXO-195, predecessorDrug, larotrectinib]
-
A.
larotrectinib
chosen
Larotrectinib is a targeted cancer therapy that selectively inhibits TRK fusion proteins and is used to treat solid tumors harboring NTRK gene fusions regardless of tumor site.
-
B.
selpercatinib
Selpercatinib is a targeted cancer therapy drug that selectively inhibits RET kinase to treat certain RET-altered thyroid and non-small cell lung cancers.
-
C.
tirabrutinib
Tirabrutinib is a selective small-molecule Bruton’s tyrosine kinase (BTK) inhibitor developed as a targeted therapy for certain B-cell malignancies and autoimmune diseases.
-
D.
neratinib
Neratinib is an oral tyrosine kinase inhibitor used primarily in the treatment of HER2-positive breast cancer, often as extended adjuvant therapy after trastuzumab.
-
E.
fam-trastuzumab deruxtecan
Fam-trastuzumab deruxtecan is an antibody–drug conjugate used primarily to treat HER2-positive cancers by delivering a cytotoxic payload directly to HER2-expressing tumor cells.
- F. None of above.
- G. Unsure - the case is ambiguous/there is not enough information to decide.
PD
Predicate disambiguation
gpt-5-mini-2025-08-07
Target predicate: predecessorDrug Context triple: [LOXO-195, predecessorDrug, larotrectinib]
-
A.
predecessor
Indicates that one entity comes before another in an ordered sequence or succession.
-
B.
predecessorName
Indicates that the value is the name of an entity that directly precedes another in an ordered sequence or lineage.
-
C.
predecessorDesign
Indicates that one design serves as the predecessor or earlier version in relation to another design.
-
D.
predecessorEstablished
Indicates that one entity was established before another, serving as its predecessor in origin or founding.
-
E.
preStatePrecursor
Indicates that one state or condition serves as a precursor to, or exists immediately before, another state in a process or sequence.
- F. None of above. chosen
Provenance (4 batches)
The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.
| Step | Stage | Batch ID | Status | When |
|---|---|---|---|---|
| creating | Elicitation | batch_69e2458185f88190b0045227ee420411 |
completed | April 17, 2026, 2:36 p.m. |
| NER | Named-entity recognition | batch_69f17cd9b3c0819096050f43a829ec0d |
completed | April 29, 2026, 3:36 a.m. |
| PD | Predicate disambiguation | batch_69eed2c32e8c8190b73bb9965ed47d64 |
completed | April 27, 2026, 3:06 a.m. |
| PDg | Predicate description generation | batch_69eeeb5681f88190821129ced752f190 |
completed | April 27, 2026, 4:51 a.m. |
Created at: April 17, 2026, 3:30 p.m.