Triple

T22456999
Position Surface form Disambiguated ID Type / Status
Subject ICH Q3A Impurities in New Drug Substances E555141 entity
Predicate relatedGuideline P148273 FINISHED
Object ICH Q3C Impurities: Guideline for Residual Solvents — NE NERFINISHED

How this triple was built (3 steps)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

NER Named-entity recognition gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: ICH Q3C Impurities: Guideline for Residual Solvents | Statement: [ICH Q3A Impurities in New Drug Substances, relatedGuideline, ICH Q3C Impurities: Guideline for Residual Solvents]
NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07 
Target entity: ICH Q3C Impurities: Guideline for Residual Solvents
Context triple: [ICH Q3A Impurities in New Drug Substances, relatedGuideline, ICH Q3C Impurities: Guideline for Residual Solvents]
  • A. ICH Q3B Impurities in New Drug Products
    ICH Q3B Impurities in New Drug Products is an ICH quality guideline that sets thresholds and requirements for identifying, reporting, and qualifying impurities present in finished pharmaceutical products.
  • B. ICH Q3A Impurities in New Drug Substances
    ICH Q3A Impurities in New Drug Substances is an international regulatory guideline that sets quality standards and thresholds for identifying, reporting, and controlling impurities in new active pharmaceutical ingredients.
  • C. ICH Q11 Development and Manufacture of Drug Substances
    ICH Q11 Development and Manufacture of Drug Substances is an ICH guideline that provides principles and expectations for the development and manufacturing of chemical and biotechnological drug substances within a quality-by-design framework.
  • D. ICH Q1 Stability Testing of New Drug Substances and Products
    ICH Q1 Stability Testing of New Drug Substances and Products is an international regulatory guideline that defines the scientific principles and study requirements for assessing the stability, shelf life, and storage conditions of new pharmaceutical substances and finished products.
  • E. ICH Q8 Pharmaceutical Development
    ICH Q8 Pharmaceutical Development is an international guideline that outlines a systematic, science- and risk-based approach to pharmaceutical product and process development, forming a core part of the ICH quality framework.
  • F. None of above. chosen
  • G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07 
Target entity: ICH Q3C Impurities: Guideline for Residual Solvents
Target entity description: ICH Q3C Impurities: Guideline for Residual Solvents is an international harmonization guideline that sets health-based limits and control strategies for residual organic solvents in pharmaceuticals to ensure product safety and quality.
  • A. ICH Q3B Impurities in New Drug Products
    ICH Q3B Impurities in New Drug Products is an ICH quality guideline that sets thresholds and requirements for identifying, reporting, and qualifying impurities present in finished pharmaceutical products.
  • B. ICH Q3A Impurities in New Drug Substances
    ICH Q3A Impurities in New Drug Substances is an international regulatory guideline that sets quality standards and thresholds for identifying, reporting, and controlling impurities in new active pharmaceutical ingredients.
  • C. ICH Q11 Development and Manufacture of Drug Substances
    ICH Q11 Development and Manufacture of Drug Substances is an ICH guideline that provides principles and expectations for the development and manufacturing of chemical and biotechnological drug substances within a quality-by-design framework.
  • D. ICH Q1 Stability Testing of New Drug Substances and Products
    ICH Q1 Stability Testing of New Drug Substances and Products is an international regulatory guideline that defines the scientific principles and study requirements for assessing the stability, shelf life, and storage conditions of new pharmaceutical substances and finished products.
  • E. ICH Q8 Pharmaceutical Development
    ICH Q8 Pharmaceutical Development is an international guideline that outlines a systematic, science- and risk-based approach to pharmaceutical product and process development, forming a core part of the ICH quality framework.
  • F. None of above. chosen

Provenance (2 batches)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step Stage Batch ID Status When
creating Elicitation batch_69e11e51fdec8190adfdf9f8a6362221 completed April 16, 2026, 5:37 p.m.
NER Named-entity recognition batch_69f15b7c428c8190847a259eef969525 completed April 29, 2026, 1:14 a.m.
Created at: April 16, 2026, 8:48 p.m.