Triple

T21057569

Position	Surface form	Disambiguated ID	Type / Status
Subject	fingolimod	`E518759`	entity
Predicate	targetsReceptor	`P142668`	FINISHED
Object	S1P3 receptor	`—`	NE NERFINISHED

How this triple was built (3 steps)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

NER Named-entity recognition gpt-5-mini

Instruction

Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).

Input

Phrase: S1P3 receptor | Statement: [fingolimod, targetsReceptor, S1P3 receptor]

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: S1P3 receptor
Context triple: [fingolimod, targetsReceptor, S1P3 receptor]

A. PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
B. CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
C. CCR5
CCR5 is a human cell-surface chemokine receptor best known as a key co-receptor for HIV entry into immune cells and as a target for both natural resistance and gene-editing interventions against HIV infection.
D. CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
E. CD22
CD22 is a B-cell–specific surface glycoprotein that functions as an inhibitory co-receptor modulating B cell receptor signaling and immune responses.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: S1P3 receptor
Target entity description: The S1P3 receptor is a G protein–coupled sphingosine-1-phosphate receptor involved in regulating vascular tone, immune cell trafficking, and cardiovascular function.

A. PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
B. CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
C. CCR5
CCR5 is a human cell-surface chemokine receptor best known as a key co-receptor for HIV entry into immune cells and as a target for both natural resistance and gene-editing interventions against HIV infection.
D. CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
E. CD22
CD22 is a B-cell–specific surface glycoprotein that functions as an inhibitory co-receptor modulating B cell receptor signaling and immune responses.
F. None of above. chosen

Provenance (2 batches)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step	Stage	Batch ID	Status	When
creating	Elicitation	`batch_69e0b5053ac48190921529544959e906`	completed	April 16, 2026, 10:08 a.m.
NER	Named-entity recognition	`batch_69e6fd81434c8190aedfddf937f82322`	completed	April 21, 2026, 4:30 a.m.

Created at: April 16, 2026, 2:37 p.m.