Triple
T15982936
| Position | Surface form | Disambiguated ID | Type / Status |
|---|---|---|---|
| Subject | Ariad Pharmaceuticals |
E387618
|
entity |
| Predicate | ponatinibBrandName |
P65955
|
FINISHED |
| Object |
Iclusig
Iclusig is a cancer medication containing ponatinib, primarily used to treat certain types of leukemia such as chronic myeloid leukemia (CML) and Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL).
|
E1188112
|
NE FINISHED |
How this triple was built (5 steps)
Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.
NER
Named-entity recognition
gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: Iclusig | Statement: [Ariad Pharmaceuticals, ponatinibBrandName, Iclusig]
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Iclusig Context triple: [Ariad Pharmaceuticals, ponatinibBrandName, Iclusig]
-
A.
Venclexta
Venclexta is a targeted cancer therapy (venetoclax) used primarily to treat certain types of leukemia by inhibiting the BCL-2 protein that helps cancer cells survive.
-
B.
Imbruvica
Imbruvica is a targeted cancer therapy (a Bruton's tyrosine kinase inhibitor) used primarily to treat certain types of blood cancers such as mantle cell lymphoma and chronic lymphocytic leukemia.
-
C.
Onpattro
Onpattro is an RNA interference (RNAi) therapeutic used to treat polyneuropathy in adults with hereditary transthyretin-mediated (hATTR) amyloidosis.
-
D.
Verzenio
Verzenio is a prescription cancer medication (abemaciclib) used primarily to treat certain types of hormone receptor–positive, HER2-negative breast cancer.
-
E.
Tasigna
Tasigna is a prescription tyrosine kinase inhibitor used primarily to treat certain types of Philadelphia chromosome–positive chronic myeloid leukemia (CML) in adults and children.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg
Description generation
gpt-5.1
Instruction
Generate a one-sentence description of the target entity. You are given a context triple in the form (subject, predicate, object), where the object is the target entity. # Instructions Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. Avoid repeating the information from the triple, unless really essential. # Response Format Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: Iclusig Triple: [Ariad Pharmaceuticals, ponatinibBrandName, Iclusig]
Generated description
Iclusig is a cancer medication containing ponatinib, primarily used to treat certain types of leukemia such as chronic myeloid leukemia (CML) and Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL).
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Iclusig Target entity description: Iclusig is a cancer medication containing ponatinib, primarily used to treat certain types of leukemia such as chronic myeloid leukemia (CML) and Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL).
-
A.
Venclexta
Venclexta is a targeted cancer therapy (venetoclax) used primarily to treat certain types of leukemia by inhibiting the BCL-2 protein that helps cancer cells survive.
-
B.
Imbruvica
Imbruvica is a targeted cancer therapy (a Bruton's tyrosine kinase inhibitor) used primarily to treat certain types of blood cancers such as mantle cell lymphoma and chronic lymphocytic leukemia.
-
C.
Onpattro
Onpattro is an RNA interference (RNAi) therapeutic used to treat polyneuropathy in adults with hereditary transthyretin-mediated (hATTR) amyloidosis.
-
D.
Verzenio
Verzenio is a prescription cancer medication (abemaciclib) used primarily to treat certain types of hormone receptor–positive, HER2-negative breast cancer.
-
E.
Tasigna
Tasigna is a prescription tyrosine kinase inhibitor used primarily to treat certain types of Philadelphia chromosome–positive chronic myeloid leukemia (CML) in adults and children.
- F. None of above. chosen
PD
Predicate disambiguation
gpt-5-mini-2025-08-07
Target predicate: ponatinibBrandName Context triple: [Ariad Pharmaceuticals, ponatinibBrandName, Iclusig]
-
A.
isProdrugOf
Indicates that one substance is a precursor form that is metabolized in the body to produce the active form of another substance.
-
B.
isPegylated
Indicates that a molecule, typically a drug or therapeutic agent, has been chemically modified by the attachment of polyethylene glycol (PEG) chains.
-
C.
sponsorDrugBrand
chosen
Indicates that one entity financially supports, endorses, or promotes a specific drug brand, typically in a commercial or regulatory context.
-
D.
hasMolecularTarget
Indicates that one entity (such as a drug or compound) is directed toward, binds to, or specifically interacts with a particular molecular target (such as a protein, receptor, or gene).
-
E.
isIndicatedAsMonotherapyFor
Indicates that a treatment is recommended or used alone, without combination with other therapies, for a particular condition or purpose.
- F. None of above.
Provenance (6 batches)
The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.
| Step | Stage | Batch ID | Status | When |
|---|---|---|---|---|
| creating | Elicitation | batch_69d86da94ccc819083d187f5dc6a123e |
completed | April 10, 2026, 3:25 a.m. |
| NER | Named-entity recognition | batch_69e17d4d08f481909f38b75e3f42d9ab |
completed | April 17, 2026, 12:22 a.m. |
| NED1 | Entity disambiguation (via context triple) | batch_69ffc3cdf7848190848e9081027dc027 |
completed | May 9, 2026, 11:31 p.m. |
| NEDg | Description generation | batch_69ffc5669c1c81909bacf61c96cb7816 |
completed | May 9, 2026, 11:38 p.m. |
| NED2 | Entity disambiguation (via description) | batch_69ffc5c7db1c8190b4e1de6f6e3ce8a0 |
completed | May 9, 2026, 11:39 p.m. |
| PD | Predicate disambiguation | batch_69e142d9d8e881909b559a3e3ca21d24 |
completed | April 16, 2026, 8:13 p.m. |
Created at: April 10, 2026, 4:54 a.m.