Triple

T1172238

Position	Surface form	Disambiguated ID	Type / Status
Subject	Aduhelm	`E24938`	entity
Predicate	clinicalTrial	`P23163`	FINISHED
Object	ENGAGE (Study 301) ENGAGE (Study 301) is a large Phase 3 clinical trial designed to evaluate the efficacy and safety of the anti-amyloid monoclonal antibody aducanumab (Aduhelm) in patients with early Alzheimer’s disease.	`E133124`	NE FINISHED

How this triple was built (4 steps)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

NER Named-entity recognition gpt-5-mini

Instruction

Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).

Input

Phrase: ENGAGE (Study 301) | Statement: [Aduhelm, clinicalTrial, ENGAGE (Study 301)]

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: ENGAGE (Study 301)
Context triple: [Aduhelm, clinicalTrial, ENGAGE (Study 301)]

A. Study 301
Study 301 is a pivotal clinical trial evaluating the efficacy and safety of the Alzheimer’s disease drug Leqembi (lecanemab) in patients with early-stage disease.
B. Jackson Heart Study
The Jackson Heart Study is a large, long-term epidemiological research project focused on understanding cardiovascular disease and its risk factors among African American communities, particularly in Jackson, Mississippi.
C. ICH E2A Clinical Safety Data Management
ICH E2A Clinical Safety Data Management is an international guideline that standardizes the collection, reporting, and evaluation of clinical safety data in drug development to support consistent pharmacovigilance and regulatory decision-making.
D. Intramural Research Program on Aging
The Intramural Research Program on Aging is a U.S. federal biomedical research program that conducts laboratory, clinical, and population studies to understand the biology of aging and age-related diseases.
E. Multi-Ethnic Study of Atherosclerosis
The Multi-Ethnic Study of Atherosclerosis is a long-term, population-based medical research study that investigates the prevalence, progression, and risk factors of cardiovascular disease across diverse ethnic groups in the United States.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NEDg Description generation gpt-5.1

Instruction

Generate a one-sentence description of the target entity. 
You are given a context triple in the form (subject, predicate, object), where the object is the target entity. 
# Instructions
Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. 
Avoid repeating the information from the triple, unless really essential.
# Response Format
Return only the sentence: "Description: [one-sentence description of the target entity]"

Input

Entity: ENGAGE (Study 301)
Triple: [Aduhelm, clinicalTrial, ENGAGE (Study 301)]

Generated description

ENGAGE (Study 301) is a large Phase 3 clinical trial designed to evaluate the efficacy and safety of the anti-amyloid monoclonal antibody aducanumab (Aduhelm) in patients with early Alzheimer’s disease.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: ENGAGE (Study 301)
Target entity description: ENGAGE (Study 301) is a large Phase 3 clinical trial designed to evaluate the efficacy and safety of the anti-amyloid monoclonal antibody aducanumab (Aduhelm) in patients with early Alzheimer’s disease.

A. Study 301
Study 301 is a pivotal clinical trial evaluating the efficacy and safety of the Alzheimer’s disease drug Leqembi (lecanemab) in patients with early-stage disease.
B. Jackson Heart Study
The Jackson Heart Study is a large, long-term epidemiological research project focused on understanding cardiovascular disease and its risk factors among African American communities, particularly in Jackson, Mississippi.
C. ICH E2A Clinical Safety Data Management
ICH E2A Clinical Safety Data Management is an international guideline that standardizes the collection, reporting, and evaluation of clinical safety data in drug development to support consistent pharmacovigilance and regulatory decision-making.
D. Intramural Research Program on Aging
The Intramural Research Program on Aging is a U.S. federal biomedical research program that conducts laboratory, clinical, and population studies to understand the biology of aging and age-related diseases.
E. Multi-Ethnic Study of Atherosclerosis
The Multi-Ethnic Study of Atherosclerosis is a long-term, population-based medical research study that investigates the prevalence, progression, and risk factors of cardiovascular disease across diverse ethnic groups in the United States.
F. None of above. chosen

Provenance (5 batches)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step	Stage	Batch ID	Status	When
creating	Elicitation	`batch_69a494082a7c819095004f423f294a64`	completed	March 1, 2026, 7:31 p.m.
NER	Named-entity recognition	`batch_69a4bf13ab648190931dea78202096e4`	completed	March 1, 2026, 10:34 p.m.
NED1	Entity disambiguation (via context triple)	`batch_69ac66879aec819098293c440a0e09a6`	completed	March 7, 2026, 5:55 p.m.
NEDg	Description generation	`batch_69ac66fd58308190bb4cb09581d4a8de`	completed	March 7, 2026, 5:57 p.m.
NED2	Entity disambiguation (via description)	`batch_69ac677e147081909d9f64884c443f82`	completed	March 7, 2026, 5:59 p.m.

Created at: March 1, 2026, 7:45 p.m.