hepatitis C virus
E902136
Hepatitis C virus is a bloodborne RNA virus that primarily infects the liver, often causing chronic hepatitis, cirrhosis, and an increased risk of liver cancer.
Statements (79)
| Predicate | Object |
|---|---|
| instanceOf |
bloodborne pathogen
ⓘ
hepatitis virus ⓘ virus ⓘ |
| associatedDisease |
acute hepatitis C
ⓘ
chronic hepatitis C ⓘ extrahepatic manifestations ⓘ hepatitis C ⓘ hepatocellular carcinoma ⓘ liver cirrhosis ⓘ membranoproliferative glomerulonephritis ⓘ mixed cryoglobulinemia ⓘ |
| diagnosedBy |
HCV RNA PCR test
ⓘ
anti-HCV antibody test ⓘ |
| discoveredBy |
Charles M. Rice
NERFINISHED
ⓘ
Harvey J. Alter NERFINISHED ⓘ Michael Houghton NERFINISHED ⓘ |
| discoveryYear | 1989 ⓘ |
| encodesProtein |
NS2 protein
NERFINISHED
ⓘ
NS3 protease-helicase NERFINISHED ⓘ NS4A protein NERFINISHED ⓘ NS4B protein NERFINISHED ⓘ NS5A protein NERFINISHED ⓘ NS5B RNA-dependent RNA polymerase NERFINISHED ⓘ core protein ⓘ envelope glycoprotein E1 ⓘ envelope glycoprotein E2 ⓘ |
| entryReceptor |
CD81
NERFINISHED
ⓘ
SR-BI NERFINISHED ⓘ claudin-1 ⓘ occludin ⓘ |
| enveloped | true ⓘ |
| family | Flaviviridae NERFINISHED ⓘ |
| genomeLength | approximately 9600 nucleotides ⓘ |
| genomeOrganization | single open reading frame ⓘ |
| genomePolarity | positive-sense ⓘ |
| genomeSegmented | non-segmented ⓘ |
| genomeStrandedness | single-stranded ⓘ |
| genomeType | single-stranded RNA ⓘ |
| genus | Hepacivirus NERFINISHED ⓘ |
| globalBurden | major cause of chronic liver disease worldwide ⓘ |
| hasGenotype |
genotype 1
ⓘ
genotype 2 ⓘ genotype 3 ⓘ genotype 4 ⓘ genotype 5 ⓘ genotype 6 ⓘ genotype 7 ⓘ |
| hasVaccine | false ⓘ |
| order | Amarillovirales NERFINISHED ⓘ |
| parentTaxon | Hepacivirus C NERFINISHED ⓘ |
| previousName | non-A, non-B hepatitis virus NERFINISHED ⓘ |
| primaryPreventionMethod |
harm reduction for injection drug use
GENERATED
ⓘ
infection control in healthcare settings GENERATED ⓘ safe injection practices GENERATED ⓘ screening of blood products GENERATED ⓘ |
| primaryTargetOrgan | liver ⓘ |
| primaryTropism | hepatocytes ⓘ |
| replicationSite | cytoplasm of hepatocytes ⓘ |
| riskFactorFor |
end-stage liver disease
ⓘ
liver transplantation ⓘ |
| shape | spherical ⓘ |
| taxonRank | species ⓘ |
| transmissionRoute |
bloodborne
ⓘ
contaminated blood transfusion ⓘ inadequately sterilized medical equipment ⓘ needle sharing ⓘ occupational exposure ⓘ parenteral ⓘ percutaneous exposure ⓘ vertical transmission ⓘ |
| treatedBy |
NS3/4A protease inhibitors
ⓘ
NS5A inhibitors NERFINISHED ⓘ NS5B polymerase inhibitors ⓘ direct-acting antivirals ⓘ glecaprevir NERFINISHED ⓘ ledipasvir ⓘ pibrentasvir NERFINISHED ⓘ sofosbuvir NERFINISHED ⓘ velpatasvir NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.