atmospheric pressure chemical ionization
E902131
Atmospheric pressure chemical ionization is a soft ionization technique used in mass spectrometry to analyze relatively less volatile and thermally stable compounds under atmospheric pressure conditions.
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
ionization technique
ⓘ
mass spectrometry ion source ⓘ soft ionization method ⓘ |
| abbreviation | APCI ⓘ |
| advantage |
good for moderately polar compounds
ⓘ
less susceptible to ion suppression than ESI for some analytes ⓘ tolerant to higher mobile phase flow rates ⓘ |
| analyzes |
less volatile compounds
ⓘ
thermally stable compounds ⓘ |
| canOperateIn | negative ion mode ⓘ |
| category | atmospheric pressure ionization technique ⓘ |
| commonlyCoupledWith |
LC–MS
NERFINISHED
ⓘ
high performance liquid chromatography ⓘ |
| commonlyUsedFor |
environmental analysis
ⓘ
metabolite profiling ⓘ pesticide analysis ⓘ pharmaceutical analysis ⓘ |
| contrastWith |
electron ionization
ⓘ
matrix-assisted laser desorption ionization ⓘ |
| developedFor | liquid chromatography–mass spectrometry ⓘ |
| environment | atmospheric pressure region outside mass spectrometer orifice ⓘ |
| ionizationMechanism |
charge transfer reactions
ⓘ
gas phase ion–molecule reactions ⓘ proton transfer reactions ⓘ |
| limitation |
less suitable for very nonvolatile analytes
ⓘ
less suitable for very thermally labile analytes ⓘ |
| operatesAt | atmospheric pressure ⓘ |
| produces |
[M+H]+ ions
ⓘ
[M−H]− ions ⓘ deprotonated molecules ⓘ protonated molecules ⓘ |
| reagentIonFormation | solvent ionization by corona discharge ⓘ |
| relatedTo |
atmospheric pressure photoionization
ⓘ
chemical ionization ⓘ electrospray ionization ⓘ |
| sampleIntroduction |
liquid effluent from LC
ⓘ
solution sprayed into heated region ⓘ |
| transferToMassAnalyzer |
sampling orifice
ⓘ
skimmer cone ⓘ |
| typicallyOperatesIn | positive ion mode GENERATED ⓘ |
| usedIn | mass spectrometry ⓘ |
| uses |
corona discharge needle
ⓘ
drying gas ⓘ heated nebulizer ⓘ nebulizing gas ⓘ reagent ions ⓘ |
| vaporizes |
analyte molecules
ⓘ
mobile phase ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.