Cancer, Ageing and Somatic Mutation
E890467
ageing research programme
cancer research programme
research programme
scientific research programme
Cancer, Ageing and Somatic Mutation is a research programme that investigates how genetic changes in cells drive cancer development and the biological processes of ageing.
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
ageing research programme
ⓘ
cancer research programme ⓘ research programme ⓘ scientific research programme ⓘ |
| aimsTo |
understand how somatic mutations accumulate in tissues
ⓘ
understand how somatic mutations contribute to ageing ⓘ understand how somatic mutations contribute to cancer ⓘ |
| examines |
how somatic evolution changes with age
ⓘ
how somatic evolution differs between tissues ⓘ interplay between somatic mutation and tissue microenvironment ⓘ |
| focusesOn |
ageing
ⓘ
cancer ⓘ somatic mutation ⓘ |
| goal |
identify mechanisms that maintain genome integrity in somatic cells
ⓘ
identify mechanisms whose failure accelerates ageing ⓘ identify mechanisms whose failure leads to cancer ⓘ link somatic mutation burden to ageing phenotypes ⓘ link somatic mutation burden to cancer risk ⓘ |
| investigates |
cellular mechanisms of DNA damage
ⓘ
cellular mechanisms of DNA repair ⓘ how cell lineages expand in tissues ⓘ how clonal expansions relate to cancer risk ⓘ mutation patterns in cancer ⓘ mutation patterns in normal tissues ⓘ |
| relatedTo |
cancer biology
ⓘ
cell biology ⓘ evolutionary biology ⓘ gerontology ⓘ molecular biology ⓘ |
| researchArea |
age-related disease
ⓘ
cancer genomics ⓘ clonal evolution ⓘ genomics ⓘ somatic mutation landscapes ⓘ tissue homeostasis ⓘ |
| studies |
age-related changes in tissue architecture
ⓘ
biological processes of ageing ⓘ cellular evolution over the human lifespan ⓘ early events in tumorigenesis ⓘ genetic changes in cells ⓘ how environmental exposures shape somatic mutation ⓘ how genetic changes drive cancer development ⓘ mutational signatures in tissues ⓘ |
| usesMethod |
bioinformatics analysis
ⓘ
computational modelling of evolution in tissues ⓘ genome sequencing ⓘ somatic mutation profiling ⓘ |
Referenced by (1)
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