dentate gyrus
E874320
The dentate gyrus is a subregion of the hippocampal formation crucial for forming new episodic memories and supporting adult neurogenesis.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
brain region
ⓘ
hippocampal subregion ⓘ |
| adultNeurogenesisOccursIn | subgranular zone ⓘ |
| associatedWith |
Alzheimer's disease
ⓘ
major depressive disorder ⓘ temporal lobe epilepsy ⓘ |
| containsCellType |
GABAergic interneuron
ⓘ
granule cell ⓘ mossy cell ⓘ neural progenitor cell ⓘ neural stem cell ⓘ |
| containsRegion | subgranular zone ⓘ |
| discoveredBy | Santiago Ramón y Cajal NERFINISHED ⓘ |
| hasFunction |
discrimination of similar contexts
ⓘ
filtering of entorhinal input ⓘ orthogonalization of input patterns ⓘ regulation of hippocampal excitability ⓘ sparse coding of cortical inputs ⓘ |
| hasHighExpressionOf |
doublecortin in immature neurons
ⓘ
progranule cell markers ⓘ |
| hasLayer |
granule cell layer
ⓘ
inner molecular layer ⓘ middle molecular layer ⓘ outer molecular layer ⓘ polymorphic layer ⓘ |
| hasSubregion |
granule cell layer of dentate gyrus
ⓘ
hilus of dentate gyrus ⓘ molecular layer of dentate gyrus ⓘ |
| involvedIn |
adult neurogenesis
ⓘ
cognitive flexibility ⓘ contextual fear conditioning ⓘ episodic memory formation ⓘ pattern separation ⓘ spatial memory ⓘ |
| locatedIn |
limbic system
NERFINISHED
ⓘ
medial temporal lobe NERFINISHED ⓘ |
| partOf |
hippocampal formation
NERFINISHED
ⓘ
hippocampus NERFINISHED ⓘ |
| projectsTo | CA3 region of hippocampus ⓘ |
| projectsVia | mossy fibers ⓘ |
| receivesInputFrom | entorhinal cortex NERFINISHED ⓘ |
| receivesInputVia | perforant path ⓘ |
| species | present in mammals ⓘ |
| supportsProcess | adult hippocampal neurogenesis ⓘ |
| synonym |
dentate area
ⓘ
fascia dentata ⓘ |
| vulnerableTo |
aging-related decline
ⓘ
seizure-induced reorganization ⓘ stress-induced changes ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.