Restless legs syndrome
E873102
Restless legs syndrome is a neurological sleep-related disorder characterized by an uncontrollable urge to move the legs, typically worsening at rest and at night.
Statements (74)
| Predicate | Object |
|---|---|
| instanceOf |
chronic condition
ⓘ
neurological disorder ⓘ sleep-related movement disorder ⓘ |
| affectsBodyPart | legs ⓘ |
| affectsSystem | nervous system ⓘ |
| hasAssociatedCondition |
Parkinson's disease
NERFINISHED
ⓘ
diabetes mellitus ⓘ end-stage renal disease ⓘ iron deficiency ⓘ iron-deficiency anemia ⓘ peripheral neuropathy ⓘ pregnancy ⓘ rheumatoid arthritis ⓘ |
| hasAssociatedNeurotransmitter | dopamine ⓘ |
| hasAssociatedNutrient | iron ⓘ |
| hasComplication | augmentation with long-term dopaminergic therapy ⓘ |
| hasCoreSymptom |
difficulty falling asleep
GENERATED
ⓘ
sleep fragmentation GENERATED ⓘ symptoms worse at rest GENERATED ⓘ symptoms worse in the evening or at night GENERATED ⓘ temporary relief with movement GENERATED ⓘ uncomfortable sensations in the legs GENERATED ⓘ urge to move the legs GENERATED ⓘ |
| hasDiagnosticCriterion |
symptoms are not solely accounted for by another medical or behavioral condition
ⓘ
symptoms are partially or totally relieved by movement ⓘ symptoms are worse in the evening or at night than during the day ⓘ symptoms begin or worsen during periods of rest or inactivity ⓘ urge to move the legs usually accompanied by uncomfortable sensations ⓘ |
| hasEpidemiology | affects a few percent of the adult population ⓘ |
| hasGeneticComponent | yes ⓘ |
| hasHeritability | often runs in families ⓘ |
| hasImpact |
increased risk of depression
ⓘ
reduced quality of life ⓘ reduced sleep quality ⓘ |
| hasNonPharmacologicTreatment |
avoiding caffeine and alcohol in the evening
GENERATED
ⓘ
hot or cold baths GENERATED ⓘ leg massage GENERATED ⓘ moderate regular exercise GENERATED ⓘ pneumatic compression devices GENERATED ⓘ sleep hygiene measures GENERATED ⓘ |
| hasOnsetPattern |
symptoms may begin in childhood or adolescence
ⓘ
symptoms often begin in adulthood ⓘ |
| hasPathophysiologyHypothesis |
brain iron deficiency
ⓘ
central dopaminergic dysfunction ⓘ |
| hasPharmacologicTreatment |
alpha-2-delta ligands
ⓘ
benzodiazepines for sleep ⓘ dopamine agonists ⓘ gabapentin NERFINISHED ⓘ iron supplementation when iron deficient ⓘ levodopa NERFINISHED ⓘ opioids in refractory cases ⓘ pregabalin NERFINISHED ⓘ |
| hasPossibleSymptom |
daytime fatigue
ⓘ
impaired concentration ⓘ mood disturbances ⓘ |
| hasPrevalence |
more common in women than in men
ⓘ
prevalence increases with age ⓘ |
| hasRiskFactor |
family history of restless legs syndrome
ⓘ
female sex ⓘ older age ⓘ pregnancy ⓘ |
| hasSubtype |
primary restless legs syndrome
ⓘ
secondary restless legs syndrome ⓘ |
| hasSynonym |
RLS
NERFINISHED
ⓘ
Willis–Ekbom disease NERFINISHED ⓘ |
| hasTypicalCourse |
symptoms may fluctuate over time
ⓘ
symptoms often progress in severity ⓘ |
| isChronic | often lifelong ⓘ |
| isClassifiedIn |
ICD-10 G25.81
ⓘ
ICD-11 8D80 NERFINISHED ⓘ |
| isDistinguishedFrom |
akathisia
ⓘ
nocturnal leg cramps ⓘ peripheral neuropathy ⓘ |
| isListedIn | DSM-5 as a sleep-wake disorder ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.