Suprachiasmatic nucleus
E873098
The suprachiasmatic nucleus is a small region in the hypothalamus that serves as the body’s master circadian clock, synchronizing daily physiological and behavioral rhythms such as the sleep–wake cycle.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
brain nucleus
ⓘ
circadian pacemaker ⓘ |
| associatedWith |
jet lag
ⓘ
shift work disorder ⓘ |
| composedOf |
GABAergic neurons
ⓘ
arginine vasopressin neurons ⓘ vasoactive intestinal peptide neurons ⓘ |
| controls | circadian rhythms in mammals ⓘ |
| discoveredIn | 20th century ⓘ |
| dorsomedial SCNFunction | outputs circadian signals ⓘ |
| expresses |
BMAL1 gene
NERFINISHED
ⓘ
CLOCK gene NERFINISHED ⓘ PER1 gene NERFINISHED ⓘ PER2 gene NERFINISHED ⓘ clock genes ⓘ |
| foundIn | mammals ⓘ |
| hasAbbreviation | SCN NERFINISHED ⓘ |
| hasFunction |
master circadian clock
ⓘ
regulation of body temperature rhythms ⓘ regulation of feeding rhythms ⓘ regulation of hormone secretion rhythms ⓘ regulation of sleep–wake cycle ⓘ synchronization of circadian rhythms ⓘ |
| hasMechanism | transcription–translation feedback loops ⓘ |
| hasNameOrigin | Latin for "above the chiasm" ⓘ |
| hasResearchUse | model for circadian biology ⓘ |
| hasSubregion |
dorsomedial SCN
ⓘ
ventrolateral SCN NERFINISHED ⓘ |
| isEntrainedBy | light–dark cycle ⓘ |
| lesionEffect |
abolition of circadian locomotor rhythms
ⓘ
disruption of sleep–wake cycle ⓘ |
| locatedAbove | optic chiasm ⓘ |
| locatedIn |
brain
ⓘ
diencephalon ⓘ |
| partOf |
anterior hypothalamus
NERFINISHED
ⓘ
hypothalamus NERFINISHED ⓘ |
| projectsTo |
dorsomedial hypothalamic nucleus
NERFINISHED
ⓘ
paraventricular nucleus of the hypothalamus NERFINISHED ⓘ pineal gland via multisynaptic pathways ⓘ subparaventricular zone NERFINISHED ⓘ |
| receivesInputFrom |
intrinsically photosensitive retinal ganglion cells
ⓘ
retina ⓘ retinohypothalamic tract NERFINISHED ⓘ |
| regulates |
chronotype
ⓘ
cortisol circadian rhythm ⓘ melatonin secretion ⓘ sleep timing ⓘ |
| usesSignal | melanopsin-based photoreception ⓘ |
| ventrolateral SCNFunction | receives photic input ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.