SARS-CoV-2 spike glycoprotein
E854994
The SARS-CoV-2 spike glycoprotein is the viral surface protein that mediates coronavirus entry into human cells and is the primary target of neutralizing antibodies and many COVID-19 vaccines.
Statements (54)
| Predicate | Object |
|---|---|
| instanceOf |
class I fusion protein
ⓘ
viral surface glycoprotein ⓘ |
| binds |
heparan sulfate
ⓘ
human ACE2 NERFINISHED ⓘ neuropilin-1 (NRP1) NERFINISHED ⓘ |
| cleavedBy |
TMPRSS2
NERFINISHED
ⓘ
cathepsins ⓘ furin ⓘ |
| enablesProcess |
fusion of viral and host membranes
ⓘ
virus attachment to host cell ⓘ |
| encodedBy | S gene of SARS-CoV-2 NERFINISHED ⓘ |
| evolves |
variants with mutations affecting immune escape
ⓘ
variants with mutations affecting transmissibility ⓘ |
| forms | homotrimer on virion surface ⓘ |
| formsComplexWith | ACE2 receptor NERFINISHED ⓘ |
| foundInTaxon | Severe acute respiratory syndrome coronavirus 2 NERFINISHED ⓘ |
| hasConformation |
RBD-down state
GENERATED
ⓘ
RBD-up state GENERATED ⓘ postfusion conformation GENERATED ⓘ prefusion conformation GENERATED ⓘ |
| hasMolecularFunction |
membrane fusion
ⓘ
receptor binding ⓘ viral entry into host cell ⓘ |
| hasNotableMutation |
D614G
GENERATED
ⓘ
E484K GENERATED ⓘ L452R GENERATED ⓘ N501Y GENERATED ⓘ P681H GENERATED ⓘ P681R GENERATED ⓘ |
| hasPart |
N-terminal domain
ⓘ
S1 subunit ⓘ S1/S2 cleavage site ⓘ S2 subunit ⓘ S2′ cleavage site ⓘ cytoplasmic tail ⓘ furin cleavage site ⓘ fusion peptide ⓘ heptad repeat 1 (HR1) ⓘ heptad repeat 2 (HR2) ⓘ receptor-binding domain ⓘ transmembrane domain ⓘ |
| lengthInAminoAcids | 1273 ⓘ |
| locatedIn | viral envelope of SARS-CoV-2 ⓘ |
| locatedOn | surface of SARS-CoV-2 virion ⓘ |
| majorAntigenOf | SARS-CoV-2 NERFINISHED ⓘ |
| postTranslationalModification |
N-linked glycosylation
ⓘ
O-linked glycosylation ⓘ |
| primaryTargetOf |
many COVID-19 vaccines
ⓘ
neutralizing antibodies in COVID-19 ⓘ |
| subjectOf | structural studies by cryo-electron microscopy ⓘ |
| targetOf |
mRNA COVID-19 vaccines
NERFINISHED
ⓘ
monoclonal antibody therapies for COVID-19 ⓘ protein subunit COVID-19 vaccines ⓘ viral vector COVID-19 vaccines ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
human adenovirus serotype 26