pregnane X receptor
E850015
Pregnane X receptor is a nuclear hormone receptor that senses a wide range of xenobiotics and endogenous compounds to regulate genes involved in drug metabolism and detoxification.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| Pregnane X receptor | 0 |
Statements (61)
| Predicate | Object |
|---|---|
| instanceOf |
nuclear receptor
ⓘ
protein ⓘ transcription factor ⓘ xenobiotic sensor ⓘ |
| activatedBy |
bile acid derivatives
ⓘ
dexamethasone NERFINISHED ⓘ hyperforin ⓘ phenobarbital ⓘ pregnenolone 16α-carbonitrile NERFINISHED ⓘ rifampicin NERFINISHED ⓘ |
| activatedState | ligand-bound heterodimer with RXRα ⓘ |
| alsoKnownAs |
NR1I2
NERFINISHED
ⓘ
PXR NERFINISHED ⓘ SXR NERFINISHED ⓘ steroid and xenobiotic receptor NERFINISHED ⓘ |
| associatedWith |
cholestatic liver disease
ⓘ
inflammatory bowel disease ⓘ metabolic disorders ⓘ |
| belongsToFamily | nuclear receptor subfamily 1 group I ⓘ |
| bindsDNAAt |
PXR response elements
ⓘ
xenobiotic response elements ⓘ |
| bindsLigand |
bile acids
ⓘ
endogenous steroids ⓘ herbal compounds ⓘ prescription drugs ⓘ xenobiotics ⓘ |
| biologicalProcess |
bile acid homeostasis
ⓘ
cholesterol metabolism ⓘ detoxification ⓘ lipid metabolism ⓘ regulation of drug clearance ⓘ xenobiotic metabolism ⓘ |
| chromosomalLocation | chromosome 3q13.33 ⓘ |
| discoveredIn | late 1990s ⓘ |
| encodedBy | NR1I2 gene NERFINISHED ⓘ |
| expressedIn |
colon
ⓘ
intestine ⓘ kidney ⓘ liver ⓘ |
| formsHeterodimerWith |
RXRα
NERFINISHED
ⓘ
retinoid X receptor alpha NERFINISHED ⓘ |
| hasDomain |
DNA-binding domain
ⓘ
ligand-binding domain ⓘ |
| hasOrtholog |
mouse Pxr
NERFINISHED
ⓘ
rat Pxr NERFINISHED ⓘ |
| involvedIn |
drug–drug interactions
ⓘ
pharmacokinetic variability ⓘ |
| organism | Homo sapiens NERFINISHED ⓘ |
| regulatesExpressionOf |
ABCB1
NERFINISHED
ⓘ
ABCC2 NERFINISHED ⓘ CYP2B6 NERFINISHED ⓘ CYP2C19 NERFINISHED ⓘ CYP2C9 NERFINISHED ⓘ CYP3A4 ⓘ MDR1 NERFINISHED ⓘ SULT2A1 ⓘ UGT1A1 NERFINISHED ⓘ drug transporters ⓘ drug-metabolizing enzymes ⓘ |
| subcellularLocation |
cytoplasm
ⓘ
nucleus ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.