VEGF-B
E823217
VEGF-B is a member of the vascular endothelial growth factor family involved in blood vessel biology and tissue survival, particularly in the heart and nervous system.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
growth factor
ⓘ
protein ⓘ vascular endothelial growth factor family member ⓘ |
| alsoKnownAs |
VEGF-B167
NERFINISHED
ⓘ
VEGF-B186 NERFINISHED ⓘ vascular endothelial growth factor B NERFINISHED ⓘ |
| associatedWith |
cardiovascular disease (experimental models)
ⓘ
ischemic heart disease (experimental models) ⓘ neurodegenerative disease (experimental models) ⓘ |
| belongsToFamily | VEGF family NERFINISHED ⓘ |
| bindsReceptor |
FLT1
NERFINISHED
ⓘ
VEGFR-1 NERFINISHED ⓘ |
| doesNotBindReceptor | VEGFR-2 NERFINISHED ⓘ |
| encodedBy | VEGFB gene NERFINISHED ⓘ |
| expressedHighlyIn |
heart
ⓘ
skeletal muscle ⓘ |
| expressedIn |
brown adipose tissue
ⓘ
cardiomyocytes ⓘ endothelial cells ⓘ nervous system ⓘ neurons ⓘ |
| forms | disulfide-linked homodimer ⓘ |
| hasIsoform |
VEGF-B167
ⓘ
VEGF-B186 NERFINISHED ⓘ |
| involvedInPathway |
VEGF signaling pathway
NERFINISHED
ⓘ
angiogenesis signaling pathway ⓘ endothelial cell survival signaling ⓘ |
| locatedOnChromosome | chromosome 11q13 (human) ⓘ |
| organism | Homo sapiens NERFINISHED ⓘ |
| postTranslationalModification | proteolytic processing ⓘ |
| relatedTo |
PlGF
NERFINISHED
ⓘ
VEGF-A NERFINISHED ⓘ VEGF-C NERFINISHED ⓘ VEGF-D NERFINISHED ⓘ |
| roleIn |
angiogenesis modulation
ⓘ
blood vessel biology ⓘ cardiac tissue survival ⓘ endothelial cell function ⓘ fatty acid uptake regulation ⓘ myocardial metabolism ⓘ neuronal survival ⓘ neuroprotection ⓘ tissue survival ⓘ vascular biology ⓘ vascular permeability regulation ⓘ |
| secreted | true ⓘ |
| therapeuticResearchArea |
cardioprotection
ⓘ
metabolic disease ⓘ neuroprotection ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.