VEGF-B
E823217
VEGF-B is a member of the vascular endothelial growth factor family involved in blood vessel biology and tissue survival, particularly in the heart and nervous system.
All labels observed (1)
| Label | Occurrences |
|---|---|
| VEGF-B canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T9812305 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: VEGF-B Context triple: [aflibercept, targets, VEGF-B]
-
A.
platelet-derived growth factor
Platelet-derived growth factor is a key signaling protein that regulates cell growth, proliferation, and angiogenesis, and plays important roles in wound healing and various pathological conditions such as cancer and fibrosis.
-
B.
IN-2
IN-2 is the standard postal-style abbreviation used to refer to Indiana's 2nd congressional district in the U.S. House of Representatives.
-
C.
aflibercept
Aflibercept is an anti-VEGF biologic drug used primarily to treat neovascular (wet) age-related macular degeneration and other retinal vascular diseases.
-
D.
EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
-
E.
B-VG
B-VG is the commonly used abbreviation for Austria’s Federal Constitutional Law, which forms the core of the country’s constitutional framework.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: VEGF-B Target entity description: VEGF-B is a member of the vascular endothelial growth factor family involved in blood vessel biology and tissue survival, particularly in the heart and nervous system.
-
A.
platelet-derived growth factor
Platelet-derived growth factor is a key signaling protein that regulates cell growth, proliferation, and angiogenesis, and plays important roles in wound healing and various pathological conditions such as cancer and fibrosis.
-
B.
IN-2
IN-2 is the standard postal-style abbreviation used to refer to Indiana's 2nd congressional district in the U.S. House of Representatives.
-
C.
aflibercept
Aflibercept is an anti-VEGF biologic drug used primarily to treat neovascular (wet) age-related macular degeneration and other retinal vascular diseases.
-
D.
EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
-
E.
B-VG
B-VG is the commonly used abbreviation for Austria’s Federal Constitutional Law, which forms the core of the country’s constitutional framework.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
growth factor
ⓘ
protein ⓘ vascular endothelial growth factor family member ⓘ |
| alsoKnownAs |
VEGF-B167
NERFINISHED
ⓘ
VEGF-B186 NERFINISHED ⓘ vascular endothelial growth factor B NERFINISHED ⓘ |
| associatedWith |
cardiovascular disease (experimental models)
ⓘ
ischemic heart disease (experimental models) ⓘ neurodegenerative disease (experimental models) ⓘ |
| belongsToFamily | VEGF family NERFINISHED ⓘ |
| bindsReceptor |
FLT1
NERFINISHED
ⓘ
VEGFR-1 NERFINISHED ⓘ |
| doesNotBindReceptor | VEGFR-2 NERFINISHED ⓘ |
| encodedBy | VEGFB gene NERFINISHED ⓘ |
| expressedHighlyIn |
heart
ⓘ
skeletal muscle ⓘ |
| expressedIn |
brown adipose tissue
ⓘ
cardiomyocytes ⓘ endothelial cells ⓘ nervous system ⓘ neurons ⓘ |
| forms | disulfide-linked homodimer ⓘ |
| hasIsoform |
VEGF-B167
ⓘ
VEGF-B186 NERFINISHED ⓘ |
| involvedInPathway |
VEGF signaling pathway
NERFINISHED
ⓘ
angiogenesis signaling pathway ⓘ endothelial cell survival signaling ⓘ |
| locatedOnChromosome | chromosome 11q13 (human) ⓘ |
| organism | Homo sapiens NERFINISHED ⓘ |
| postTranslationalModification | proteolytic processing ⓘ |
| relatedTo |
PlGF
NERFINISHED
ⓘ
VEGF-A NERFINISHED ⓘ VEGF-C NERFINISHED ⓘ VEGF-D NERFINISHED ⓘ |
| roleIn |
angiogenesis modulation
ⓘ
blood vessel biology ⓘ cardiac tissue survival ⓘ endothelial cell function ⓘ fatty acid uptake regulation ⓘ myocardial metabolism ⓘ neuronal survival ⓘ neuroprotection ⓘ tissue survival ⓘ vascular biology ⓘ vascular permeability regulation ⓘ |
| secreted | true ⓘ |
| therapeuticResearchArea |
cardioprotection
ⓘ
metabolic disease ⓘ neuroprotection ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: VEGF-B Description of subject: VEGF-B is a member of the vascular endothelial growth factor family involved in blood vessel biology and tissue survival, particularly in the heart and nervous system.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.