vascular endothelial growth factor A

E823216

angiogenic factor growth factor protein signaling molecule

Vascular endothelial growth factor A (VEGF-A) is a key signaling protein that promotes the growth of new blood vessels and increases vascular permeability, playing a central role in angiogenesis and various diseases such as cancer and eye disorders.

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Observed surface forms (2)

Surface form	Occurrences
Vascular endothelial growth factor A	0
VEGF-A	1

Statements (70)

Predicate	Object
instanceOf	angiogenic factor ⓘ growth factor ⓘ protein ⓘ signaling molecule ⓘ
actsOnCellType	endothelial cell ⓘ vascular smooth muscle cell (indirectly) ⓘ
associatedWithDisease	age-related macular degeneration ⓘ cancer ⓘ diabetic retinopathy ⓘ neovascular glaucoma ⓘ pre-eclampsia (dysregulated signaling) ⓘ psoriasis ⓘ retinal vein occlusion ⓘ rheumatoid arthritis ⓘ
bindsTo	VEGFR-1 NERFINISHED ⓘ VEGFR-2 NERFINISHED ⓘ neuropilin-1 NERFINISHED ⓘ neuropilin-2 NERFINISHED ⓘ
discoveredBy	Napoleone Ferrara NERFINISHED ⓘ
encodedBy	VEGFA gene NERFINISHED ⓘ
foundInTaxon	Homo sapiens NERFINISHED ⓘ
hasAbbreviation	VEGF-A NERFINISHED ⓘ
hasAlternativeName	VEGF ⓘ vascular permeability factor NERFINISHED ⓘ
hasBiologicalProcess	angiogenesis ⓘ endothelial cell migration ⓘ endothelial cell proliferation ⓘ lymphangiogenesis (indirectly) ⓘ tumor angiogenesis ⓘ vascular permeability increase ⓘ vasculogenesis ⓘ wound healing ⓘ
hasCellularLocation	extracellular space ⓘ secreted protein ⓘ
hasEffect	increases vascular permeability ⓘ promotes blood vessel formation ⓘ promotes endothelial cell survival ⓘ stimulates nitric oxide production ⓘ
hasIsoform	VEGF121 NERFINISHED ⓘ VEGF165 NERFINISHED ⓘ VEGF189 NERFINISHED ⓘ VEGF206 NERFINISHED ⓘ
hasMolecularFunction	growth factor activity ⓘ receptor binding ⓘ vascular endothelial growth factor receptor binding ⓘ
inducedBy	HIF-1α NERFINISHED ⓘ hypoxia ⓘ inflammatory cytokines ⓘ
involvedInPathway	MAPK signaling pathway NERFINISHED ⓘ PI3K-Akt signaling pathway NERFINISHED ⓘ VEGF signaling pathway NERFINISHED ⓘ focal adhesion pathway ⓘ
locatedOnChromosome	human chromosome 6 ⓘ
partOf	vascular endothelial growth factor family ⓘ
posttranslationalModification	glycosylation ⓘ
regulates	angiogenic sprouting ⓘ endothelial cell survival ⓘ vascular permeability ⓘ
secretedBy	endothelial cell ⓘ fibroblast ⓘ macrophage ⓘ platelet ⓘ smooth muscle cell ⓘ tumor cell ⓘ
targetOfDrug	aflibercept NERFINISHED ⓘ bevacizumab NERFINISHED ⓘ brolucizumab NERFINISHED ⓘ faricimab NERFINISHED ⓘ pegaptanib NERFINISHED ⓘ ranibizumab NERFINISHED ⓘ

Referenced by (2)

Full triples — surface form annotated when it differs from this entity's canonical label.

aflibercept → targets → vascular endothelial growth factor A ⓘ

this entity surface form: VEGF-A