folinic acid (leucovorin)
E822405
Folinic acid (leucovorin) is a reduced form of folic acid used clinically to enhance the effects of certain chemotherapy drugs like fluorouracil and to "rescue" normal cells from the toxic effects of folate antagonists such as methotrexate.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| folinic acid | 0 |
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
antidote
ⓘ
antineoplastic adjunct ⓘ chemical compound ⓘ pharmaceutical drug ⓘ vitamin B9 derivative ⓘ |
| activeIsomer | L-folinic acid ⓘ |
| antidoteFor |
methotrexate
NERFINISHED
ⓘ
pyrimethamine ⓘ trimethoprim ⓘ |
| belongsTo | folate analogs ⓘ |
| bypassesInhibitionOf | dihydrofolate reductase NERFINISHED ⓘ |
| commonAdverseEffect |
allergic reactions
ⓘ
diarrhea ⓘ nausea ⓘ vomiting ⓘ |
| doesNotRequire | dihydrofolate reductase for activation ⓘ |
| enhancesEffectOf | fluorouracil NERFINISHED ⓘ |
| hasATCCode |
L01BA04
ⓘ
V03AF03 ⓘ |
| hasChemicalFormula | C20H23N7O7 ⓘ |
| hasMolarMass | 473.44 g/mol ⓘ |
| hasPregnancyCategory | generally considered low risk when clinically indicated ⓘ |
| hasRouteOfAdministration |
intramuscular
ⓘ
intravenous ⓘ oral ⓘ |
| hasSynonym |
5-formyl-THF
ⓘ
5-formyltetrahydrofolate ⓘ calcium folinate NERFINISHED ⓘ citrovorum factor NERFINISHED ⓘ leucovorin NERFINISHED ⓘ leucovorin calcium ⓘ |
| isEnantiomerMixture | racemic mixture of D- and L-forms ⓘ |
| isFormOf | tetrahydrofolate ⓘ |
| isMarketedAs |
Calcium Folinate
NERFINISHED
ⓘ
Leucovorin NERFINISHED ⓘ Wellcovorin NERFINISHED ⓘ |
| isOn | World Health Organization Model List of Essential Medicines NERFINISHED ⓘ |
| isReducedFormOf | folic acid ⓘ |
| mayReduceEffectOf | antiepileptic drugs such as phenobarbital, phenytoin, primidone ⓘ |
| mechanismOfAction | stabilizes binding of fluorodeoxyuridylate to thymidylate synthase ⓘ |
| protects | normal cells from high-dose methotrexate toxicity ⓘ |
| usedFor |
advanced colorectal carcinoma
ⓘ
colorectal cancer ⓘ megaloblastic anemia due to folate deficiency when oral therapy not feasible ⓘ methotrexate toxicity rescue ⓘ osteosarcoma regimens with high-dose methotrexate ⓘ overdose of folate antagonists ⓘ palliative treatment of colorectal cancer ⓘ prevention of methotrexate-induced mucositis ⓘ |
| usedWith | fluorouracil ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.