aromatic L-amino acid decarboxylase
E804593
Aromatic L-amino acid decarboxylase is a pyridoxal phosphate–dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids to produce key neurotransmitters such as dopamine and serotonin.
All labels observed (1)
| Label | Occurrences |
|---|---|
| aromatic L-amino acid decarboxylase canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T9524772 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: aromatic L-amino acid decarboxylase Context triple: [levodopa, metabolizedBy, aromatic L-amino acid decarboxylase]
-
A.
levodopa
Levodopa is a cornerstone medication for managing Parkinson’s disease symptoms by replenishing the brain’s depleted dopamine levels.
-
B.
ase
"ase" is the ISO 639-3 language code assigned to American Sign Language, the primary sign language used by Deaf communities in the United States and parts of Canada.
-
C.
GABA
GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the mammalian central nervous system, crucial for reducing neuronal excitability and regulating muscle tone and anxiety.
-
D.
Activase
Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
-
E.
MAO
MAO is a contemporary art gallery and exhibition space in Oxford, England, known for showcasing innovative modern and contemporary art.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: aromatic L-amino acid decarboxylase Target entity description: Aromatic L-amino acid decarboxylase is a pyridoxal phosphate–dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids to produce key neurotransmitters such as dopamine and serotonin.
-
A.
levodopa
Levodopa is a cornerstone medication for managing Parkinson’s disease symptoms by replenishing the brain’s depleted dopamine levels.
-
B.
ase
"ase" is the ISO 639-3 language code assigned to American Sign Language, the primary sign language used by Deaf communities in the United States and parts of Canada.
-
C.
GABA
GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the mammalian central nervous system, crucial for reducing neuronal excitability and regulating muscle tone and anxiety.
-
D.
Activase
Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
-
E.
MAO
MAO is a contemporary art gallery and exhibition space in Oxford, England, known for showcasing innovative modern and contemporary art.
- F. None of above. chosen
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
decarboxylase
ⓘ
enzyme ⓘ pyridoxal phosphate–dependent enzyme ⓘ |
| associatedWithDisease |
Parkinson's disease
NERFINISHED
ⓘ
aromatic L-amino acid decarboxylase deficiency ⓘ dopamine-serotonin deficiency syndrome ⓘ |
| catalyzesReaction |
5-hydroxy-L-tryptophan + H+ → serotonin + CO2
ⓘ
L-DOPA + H+ → dopamine + CO2 ⓘ L-phenylalanine + H+ → phenethylamine + CO2 ⓘ L-tryptophan + H+ → tryptamine + CO2 ⓘ L-tyrosine + H+ → tyramine + CO2 ⓘ |
| cellularLocation | cytosol ⓘ |
| chromosomalLocationOfGene | human chromosome 7p12.2 ⓘ |
| encodedByGene | DDC gene ⓘ |
| formsComplex | homodimer ⓘ |
| foundInOrganism |
Homo sapiens
NERFINISHED
ⓘ
Mus musculus NERFINISHED ⓘ Rattus norvegicus NERFINISHED ⓘ |
| foundInTissue |
brain
ⓘ
pancreatic islets ⓘ peripheral nervous system ⓘ |
| hasCofactor | pyridoxal 5'-phosphate ⓘ |
| hasECNumber | 4.1.1.28 ⓘ |
| hasEnzymeClassification | lyase ⓘ |
| hasEnzymeCommissionClass | carboxy-lyases ⓘ |
| hasSynonym |
AADC
ⓘ
DDC NERFINISHED ⓘ DOPA decarboxylase NERFINISHED ⓘ L-dopa decarboxylase NERFINISHED ⓘ aromatic L-amino-acid decarboxylase ⓘ |
| isTargetOfDrug |
benserazide
NERFINISHED
ⓘ
carbidopa ⓘ methyldopa NERFINISHED ⓘ |
| molecularFunction | aromatic-L-amino-acid decarboxylase activity ⓘ |
| participatesIn |
catecholamine biosynthetic process
ⓘ
dopamine biosynthetic process ⓘ monoamine neurotransmitter biosynthetic process ⓘ serotonin biosynthetic process ⓘ |
| product |
carbon dioxide
ⓘ
dopamine ⓘ phenethylamine ⓘ serotonin ⓘ tryptamine ⓘ tyramine ⓘ |
| requires | pyridoxal phosphate ⓘ |
| substrate |
5-hydroxy-L-tryptophan
ⓘ
L-DOPA ⓘ L-phenylalanine ⓘ L-tryptophan ⓘ L-tyrosine ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: aromatic L-amino acid decarboxylase Description of subject: Aromatic L-amino acid decarboxylase is a pyridoxal phosphate–dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids to produce key neurotransmitters such as dopamine and serotonin.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.