aromatic L-amino acid decarboxylase
E804593
Aromatic L-amino acid decarboxylase is a pyridoxal phosphate–dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids to produce key neurotransmitters such as dopamine and serotonin.
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
decarboxylase
ⓘ
enzyme ⓘ pyridoxal phosphate–dependent enzyme ⓘ |
| associatedWithDisease |
Parkinson's disease
NERFINISHED
ⓘ
aromatic L-amino acid decarboxylase deficiency ⓘ dopamine-serotonin deficiency syndrome ⓘ |
| catalyzesReaction |
5-hydroxy-L-tryptophan + H+ → serotonin + CO2
ⓘ
L-DOPA + H+ → dopamine + CO2 ⓘ L-phenylalanine + H+ → phenethylamine + CO2 ⓘ L-tryptophan + H+ → tryptamine + CO2 ⓘ L-tyrosine + H+ → tyramine + CO2 ⓘ |
| cellularLocation | cytosol ⓘ |
| chromosomalLocationOfGene | human chromosome 7p12.2 ⓘ |
| encodedByGene | DDC gene ⓘ |
| formsComplex | homodimer ⓘ |
| foundInOrganism |
Homo sapiens
NERFINISHED
ⓘ
Mus musculus NERFINISHED ⓘ Rattus norvegicus NERFINISHED ⓘ |
| foundInTissue |
brain
ⓘ
pancreatic islets ⓘ peripheral nervous system ⓘ |
| hasCofactor | pyridoxal 5'-phosphate ⓘ |
| hasECNumber | 4.1.1.28 ⓘ |
| hasEnzymeClassification | lyase ⓘ |
| hasEnzymeCommissionClass | carboxy-lyases ⓘ |
| hasSynonym |
AADC
ⓘ
DDC NERFINISHED ⓘ DOPA decarboxylase NERFINISHED ⓘ L-dopa decarboxylase NERFINISHED ⓘ aromatic L-amino-acid decarboxylase ⓘ |
| isTargetOfDrug |
benserazide
NERFINISHED
ⓘ
carbidopa ⓘ methyldopa NERFINISHED ⓘ |
| molecularFunction | aromatic-L-amino-acid decarboxylase activity ⓘ |
| participatesIn |
catecholamine biosynthetic process
ⓘ
dopamine biosynthetic process ⓘ monoamine neurotransmitter biosynthetic process ⓘ serotonin biosynthetic process ⓘ |
| product |
carbon dioxide
ⓘ
dopamine ⓘ phenethylamine ⓘ serotonin ⓘ tryptamine ⓘ tyramine ⓘ |
| requires | pyridoxal phosphate ⓘ |
| substrate |
5-hydroxy-L-tryptophan
ⓘ
L-DOPA ⓘ L-phenylalanine ⓘ L-tryptophan ⓘ L-tyrosine ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.