nigrostriatal pathway
E804590
The nigrostriatal pathway is a major dopaminergic tract in the brain that connects the substantia nigra to the striatum and is crucial for the control of movement, with degeneration in this pathway underlying Parkinson’s disease.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
dopaminergic pathway
ⓘ
neural pathway ⓘ |
| affectedBy |
MPTP neurotoxin
ⓘ
neuroleptic drugs ⓘ typical antipsychotics ⓘ |
| associatedWithDisease |
Huntington's disease
NERFINISHED
ⓘ
Parkinson's disease NERFINISHED ⓘ drug-induced parkinsonism ⓘ multiple system atrophy NERFINISHED ⓘ progressive supranuclear palsy NERFINISHED ⓘ |
| belongsTo | central nervous system ⓘ |
| connectsFrom | substantia nigra pars compacta ⓘ |
| connectsTo |
caudate nucleus
NERFINISHED
ⓘ
putamen ⓘ striatum ⓘ |
| degenerationLeadsTo |
akinesia
ⓘ
bradykinesia ⓘ gait disturbance ⓘ postural instability ⓘ resting tremor ⓘ rigidity ⓘ |
| discoveredInContextOf | basal ganglia research ⓘ |
| hasAxonTerminalLocation |
caudate nucleus
NERFINISHED
ⓘ
dorsal striatum ⓘ putamen NERFINISHED ⓘ |
| hasCellBodyLocation | substantia nigra pars compacta NERFINISHED ⓘ |
| hasDirection | efferent projection from midbrain to forebrain ⓘ |
| hasFunction |
control of voluntary movement
ⓘ
modulation of habit learning ⓘ modulation of procedural learning ⓘ regulation of motor planning ⓘ regulation of movement execution ⓘ regulation of movement initiation ⓘ |
| hasNeurotransmitter | dopamine ⓘ |
| involvesReceptor |
dopamine D1 receptor
NERFINISHED
ⓘ
dopamine D2 receptor NERFINISHED ⓘ dopamine D3 receptor NERFINISHED ⓘ dopamine D4 receptor ⓘ dopamine D5 receptor NERFINISHED ⓘ |
| isMajor | dopaminergic tract in the brain ⓘ |
| locatedIn | brain ⓘ |
| partOf |
basal ganglia circuitry
ⓘ
extrapyramidal motor system ⓘ |
| projectsTo | medium spiny neurons of the striatum ⓘ |
| targetOf |
COMT inhibitors
ⓘ
L-DOPA therapy ⓘ MAO-B inhibitors ⓘ dopamine agonists ⓘ |
| usesNeurotransmitter | dopamine ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.