subthalamic nucleus
E804588
The subthalamic nucleus is a small, lens-shaped structure in the basal ganglia that plays a key role in regulating movement and is critically involved in the pathophysiology and treatment of Parkinson’s disease.
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
brain structure
ⓘ
component of basal ganglia circuitry ⓘ subcortical nucleus ⓘ |
| bloodSupply |
branches of posterior cerebral artery
ⓘ
posterior communicating artery branches ⓘ |
| connectedWith |
limbic system
NERFINISHED
ⓘ
prefrontal cortex NERFINISHED ⓘ |
| cytoarchitecture | densely packed small neurons ⓘ |
| hasNeurotransmitterProfile | primarily glutamatergic ⓘ |
| hasSubregion |
associative territory
ⓘ
limbic territory ⓘ motor territory ⓘ |
| involvedIn |
pathophysiology of Parkinson's disease
ⓘ
treatment of Parkinson's disease ⓘ |
| lesionAssociatedWith | hemiballismus ⓘ |
| locatedIn |
forebrain
ⓘ
human brain ⓘ |
| overactivityAssociatedWith | Parkinsonian akinesia ⓘ |
| partOf |
basal ganglia
ⓘ
diencephalon NERFINISHED ⓘ subthalamus ⓘ |
| playsRoleIn |
action selection
ⓘ
cognitive functions ⓘ decision making ⓘ hyperdirect pathway of basal ganglia ⓘ impulse control ⓘ indirect pathway of basal ganglia ⓘ inhibition of movement ⓘ motor control ⓘ regulation of movement ⓘ |
| projectsTo |
external segment of globus pallidus
ⓘ
internal segment of globus pallidus NERFINISHED ⓘ substantia nigra pars reticulata ⓘ |
| receivesInputFrom |
brainstem nuclei
ⓘ
cerebral cortex ⓘ external segment of globus pallidus ⓘ motor cortex NERFINISHED ⓘ premotor cortex NERFINISHED ⓘ supplementary motor area NERFINISHED ⓘ thalamus NERFINISHED ⓘ |
| shape | lens-shaped ⓘ |
| stimulationImproves |
Parkinsonian motor symptoms
ⓘ
bradykinesia ⓘ rigidity ⓘ tremor ⓘ |
| targetOf |
deep brain stimulation
ⓘ
functional neurosurgery ⓘ |
| taxon | Homo sapiens NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.