CD32
E747115
CD32 is a low-affinity Fc gamma receptor (FcγRII) found on various immune cells that plays a key role in modulating antibody-dependent immune responses.
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
Fc gamma receptor
ⓘ
cell surface receptor ⓘ immune receptor ⓘ protein ⓘ |
| bindsTo | Fc region of IgG ⓘ |
| encodedBy |
FCGR2A
NERFINISHED
ⓘ
FCGR2B NERFINISHED ⓘ FCGR2C NERFINISHED ⓘ |
| expressedOn |
B cells
NERFINISHED
ⓘ
basophils ⓘ dendritic cells ⓘ eosinophils ⓘ macrophages ⓘ mast cells ⓘ monocytes ⓘ neutrophils ⓘ platelets ⓘ some NK cells ⓘ |
| hasAffinityFor | IgG ⓘ |
| hasAffinityType | low-affinity ⓘ |
| hasAlternativeName |
Fc gamma receptor II
NERFINISHED
ⓘ
FcγRII NERFINISHED ⓘ FcγRII receptor NERFINISHED ⓘ |
| hasBiologicalProcess |
B cell activation regulation
ⓘ
antibody-dependent immune response ⓘ antigen presentation modulation ⓘ immune complex clearance ⓘ inflammatory response modulation ⓘ phagocytosis regulation ⓘ |
| hasDomain |
cytoplasmic tail
ⓘ
extracellular Ig-like domain ⓘ transmembrane domain ⓘ |
| hasIsoform |
activating FcγRIIA
ⓘ
activating FcγRIIC ⓘ inhibitory FcγRIIB NERFINISHED ⓘ |
| hasMolecularFunction |
IgG binding
ⓘ
immune receptor activity ⓘ |
| hasSignalingMotif |
ITAM (in FcγRIIA and FcγRIIC)
ⓘ
ITIM (in FcγRIIB) ⓘ |
| hasSubtype |
CD32A
ⓘ
CD32B ⓘ CD32C ⓘ |
| involvedIn |
allergic inflammation regulation
ⓘ
autoimmune disease pathogenesis ⓘ |
| locatedIn | plasma membrane ⓘ |
| memberOf |
Fc gamma receptor family
NERFINISHED
ⓘ
immunoglobulin superfamily NERFINISHED ⓘ |
| modulates |
antibody-dependent cellular cytotoxicity
ⓘ
antibody-dependent cellular phagocytosis ⓘ |
| species | Homo sapiens ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.