RNA world hypothesis

E725896

scientific hypothesis

The RNA world hypothesis proposes that early life on Earth was based on self-replicating RNA molecules that both stored genetic information and catalyzed chemical reactions before the evolution of DNA and proteins.

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All labels observed (1)

Label	Occurrences
RNA world hypothesis canonical	1

Statements (48)

Predicate	Object
instanceOf	scientific hypothesis ⓘ
addresses	how life originated from non-living chemistry ⓘ transition from prebiotic chemistry to biological evolution ⓘ
associatedWith	Walter Gilbert NERFINISHED ⓘ
basedOn	ability of RNA to store genetic information ⓘ dual role of RNA as information carrier and catalyst ⓘ existence of catalytic RNA (ribozymes) ⓘ
coinedBy	Walter Gilbert NERFINISHED ⓘ
coinedIn	1986 ⓘ
contrastedWith	lipid world hypothesis ⓘ metabolism-first hypotheses ⓘ protein-first hypotheses ⓘ
field	abiogenesis ⓘ biochemistry ⓘ evolutionary biology ⓘ molecular biology ⓘ
implies	an early stage of life with RNA genomes ⓘ modern DNA–RNA–protein system evolved from an earlier RNA-based system ⓘ proteins and DNA evolved later than RNA ⓘ
influences	experimental research on prebiotic RNA synthesis ⓘ models of early evolution and genetic systems ⓘ studies of minimal self-replicating systems ⓘ
openQuestion	how RNA replication without enzymes was achieved ⓘ how long RNA genomes could remain stable in early Earth conditions ⓘ how prebiotic synthesis of ribonucleotides occurred ⓘ how proteins became the dominant biological catalysts ⓘ how the transition from RNA genomes to DNA genomes occurred ⓘ
proposes	RNA molecules once catalyzed chemical reactions ⓘ RNA molecules once performed roles now carried out by both DNA and proteins ⓘ RNA molecules once stored genetic information ⓘ RNA preceded DNA and proteins in biological evolution ⓘ early life on Earth was based on RNA ⓘ self-replicating RNA molecules existed before cells with DNA genomes ⓘ
publishedIn	Nature NERFINISHED ⓘ
relatedConcept	DNA world ⓘ central dogma of molecular biology ⓘ prebiotic chemistry ⓘ protein world ⓘ protocell ⓘ ribosome ⓘ ribozymes ⓘ self-replicating molecules ⓘ
supportedBy	catalytic activity of the ribosome’s rRNA ⓘ central role of RNA in translation ⓘ discovery of ribozymes ⓘ in vitro selection of self-ligating and self-cleaving RNAs ⓘ laboratory evolution of catalytic RNAs ⓘ presence of RNA cofactors such as ATP and NAD+ ⓘ

Referenced by (1)

Full triples — surface form annotated when it differs from this entity's canonical label.

Haldane–Oparin hypothesis of the origin of life → relatedConcept → RNA world hypothesis ⓘ