Leloir pathway of galactose metabolism
E715835
The Leloir pathway of galactose metabolism is the primary biochemical route by which cells convert galactose into glucose-1-phosphate for entry into central energy and biosynthetic pathways.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
galactose catabolic pathway
ⓘ
metabolic pathway ⓘ |
| associatedWithDisease |
classic galactosemia
ⓘ
epimerase deficiency galactosemia ⓘ galactokinase deficiency ⓘ |
| convertsTo |
galactose-1-phosphate
ⓘ
glucose-1-phosphate ⓘ |
| discoveredBy | Luis Federico Leloir NERFINISHED ⓘ |
| discoveryAward | Nobel Prize in Chemistry 1970 NERFINISHED ⓘ |
| essentialFor |
lactose metabolism
ⓘ
utilization of dietary galactose ⓘ |
| feedsInto |
glycogen synthesis via glucose-1-phosphate
ⓘ
glycolysis via glucose-6-phosphate ⓘ |
| foundInTaxon |
Escherichia coli
NERFINISHED
ⓘ
Homo sapiens NERFINISHED ⓘ Mus musculus NERFINISHED ⓘ Saccharomyces cerevisiae NERFINISHED ⓘ |
| hasCofactor |
ATP
ⓘ
NAD+ ⓘ UTP ⓘ |
| hasEnzyme |
UDP-galactose 4-epimerase
NERFINISHED
ⓘ
galactokinase ⓘ galactose-1-phosphate uridylyltransferase ⓘ |
| hasInput | D-galactose ⓘ |
| hasOutput |
UDP-galactose
ⓘ
UDP-glucose ⓘ glucose-1-phosphate ⓘ |
| hasPrimaryFunction | conversion of galactose to glucose-1-phosphate ⓘ |
| hasStep |
UDP-galactose 4-epimerase reaction
ⓘ
galactokinase reaction ⓘ galactose-1-phosphate uridylyltransferase reaction ⓘ |
| linkedToPathway |
gluconeogenesis
ⓘ
glycogen metabolism ⓘ glycolysis ⓘ |
| namedAfter | Luis Federico Leloir NERFINISHED ⓘ |
| occursIn | cytosol ⓘ |
| partOf |
carbohydrate metabolism
ⓘ
central carbon metabolism ⓘ energy metabolism ⓘ galactose metabolism ⓘ |
| providesPrecursorFor |
glycolipid biosynthesis
ⓘ
glycoprotein biosynthesis ⓘ |
| regulatesLevelOf |
UDP-galactose
ⓘ
galactose ⓘ |
| subclassOf |
carbohydrate metabolism pathway
ⓘ
monosaccharide metabolism pathway ⓘ |
| usesIntermediate |
UDP-galactose
ⓘ
UDP-glucose ⓘ galactose-1-phosphate ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.