Leloir pathway of galactose metabolism
E715835
The Leloir pathway of galactose metabolism is the primary biochemical route by which cells convert galactose into glucose-1-phosphate for entry into central energy and biosynthetic pathways.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Leloir pathway of galactose metabolism canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T8167324 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
Target entity: Leloir pathway of galactose metabolism Context triple: [Luis Federico Leloir, knownFor, Leloir pathway of galactose metabolism]
-
A.
Sharpless aminohydroxylation
Sharpless aminohydroxylation is a stereoselective chemical reaction that converts alkenes into vicinal amino alcohols using a chiral catalyst, widely used in asymmetric synthesis.
-
B.
Committee on Molecular Metabolism and Nutrition
The Committee on Molecular Metabolism and Nutrition is an academic unit at the University of Chicago focused on research and graduate education in the molecular mechanisms underlying metabolism and nutritional biology.
-
C.
one gene–one enzyme hypothesis
The one gene–one enzyme hypothesis is a foundational concept in genetics proposing that each gene encodes a specific enzyme that affects a single step in a metabolic pathway.
-
D.
Barton–McCombie deoxygenation
Barton–McCombie deoxygenation is an organic chemistry reaction that converts alcohols into the corresponding hydrocarbons via radical-mediated removal of the hydroxyl group.
-
E.
Calvin cycle
The Calvin cycle is the series of biochemical reactions in photosynthetic organisms that use carbon dioxide and energy-rich molecules (ATP and NADPH) to synthesize organic sugars.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
Target entity: Leloir pathway of galactose metabolism Target entity description: The Leloir pathway of galactose metabolism is the primary biochemical route by which cells convert galactose into glucose-1-phosphate for entry into central energy and biosynthetic pathways.
-
A.
Sharpless aminohydroxylation
Sharpless aminohydroxylation is a stereoselective chemical reaction that converts alkenes into vicinal amino alcohols using a chiral catalyst, widely used in asymmetric synthesis.
-
B.
Committee on Molecular Metabolism and Nutrition
The Committee on Molecular Metabolism and Nutrition is an academic unit at the University of Chicago focused on research and graduate education in the molecular mechanisms underlying metabolism and nutritional biology.
-
C.
one gene–one enzyme hypothesis
The one gene–one enzyme hypothesis is a foundational concept in genetics proposing that each gene encodes a specific enzyme that affects a single step in a metabolic pathway.
-
D.
Barton–McCombie deoxygenation
Barton–McCombie deoxygenation is an organic chemistry reaction that converts alcohols into the corresponding hydrocarbons via radical-mediated removal of the hydroxyl group.
-
E.
Calvin cycle
The Calvin cycle is the series of biochemical reactions in photosynthetic organisms that use carbon dioxide and energy-rich molecules (ATP and NADPH) to synthesize organic sugars.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
galactose catabolic pathway
ⓘ
metabolic pathway ⓘ |
| associatedWithDisease |
classic galactosemia
ⓘ
epimerase deficiency galactosemia ⓘ galactokinase deficiency ⓘ |
| convertsTo |
galactose-1-phosphate
ⓘ
glucose-1-phosphate ⓘ |
| discoveredBy | Luis Federico Leloir NERFINISHED ⓘ |
| discoveryAward | Nobel Prize in Chemistry 1970 NERFINISHED ⓘ |
| essentialFor |
lactose metabolism
ⓘ
utilization of dietary galactose ⓘ |
| feedsInto |
glycogen synthesis via glucose-1-phosphate
ⓘ
glycolysis via glucose-6-phosphate ⓘ |
| foundInTaxon |
Escherichia coli
NERFINISHED
ⓘ
Homo sapiens NERFINISHED ⓘ Mus musculus NERFINISHED ⓘ Saccharomyces cerevisiae NERFINISHED ⓘ |
| hasCofactor |
ATP
ⓘ
NAD+ ⓘ UTP ⓘ |
| hasEnzyme |
UDP-galactose 4-epimerase
NERFINISHED
ⓘ
galactokinase ⓘ galactose-1-phosphate uridylyltransferase ⓘ |
| hasInput | D-galactose ⓘ |
| hasOutput |
UDP-galactose
ⓘ
UDP-glucose ⓘ glucose-1-phosphate ⓘ |
| hasPrimaryFunction | conversion of galactose to glucose-1-phosphate ⓘ |
| hasStep |
UDP-galactose 4-epimerase reaction
ⓘ
galactokinase reaction ⓘ galactose-1-phosphate uridylyltransferase reaction ⓘ |
| linkedToPathway |
gluconeogenesis
ⓘ
glycogen metabolism ⓘ glycolysis ⓘ |
| namedAfter | Luis Federico Leloir NERFINISHED ⓘ |
| occursIn | cytosol ⓘ |
| partOf |
carbohydrate metabolism
ⓘ
central carbon metabolism ⓘ energy metabolism ⓘ galactose metabolism ⓘ |
| providesPrecursorFor |
glycolipid biosynthesis
ⓘ
glycoprotein biosynthesis ⓘ |
| regulatesLevelOf |
UDP-galactose
ⓘ
galactose ⓘ |
| subclassOf |
carbohydrate metabolism pathway
ⓘ
monosaccharide metabolism pathway ⓘ |
| usesIntermediate |
UDP-galactose
ⓘ
UDP-glucose ⓘ galactose-1-phosphate ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Subject: Leloir pathway of galactose metabolism Description of subject: The Leloir pathway of galactose metabolism is the primary biochemical route by which cells convert galactose into glucose-1-phosphate for entry into central energy and biosynthetic pathways.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.