platelet-derived growth factor
E681666
Platelet-derived growth factor is a key signaling protein that regulates cell growth, proliferation, and angiogenesis, and plays important roles in wound healing and various pathological conditions such as cancer and fibrosis.
All labels observed (1)
| Label | Occurrences |
|---|---|
| platelet-derived growth factor canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T7685947 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: platelet-derived growth factor Context triple: [Carl-Henrik Heldin, fieldOfWork, platelet-derived growth factor]
-
A.
IN-2
IN-2 is the standard postal-style abbreviation used to refer to Indiana's 2nd congressional district in the U.S. House of Representatives.
-
B.
PDG
PDG is an abbreviation commonly used for the Policy Development Group, an organization focused on formulating and advising on policy matters.
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C.
EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
-
D.
HGF
HGF is the abbreviation for the Helmholtz Association, Germany’s largest scientific research organization spanning multiple disciplines and large-scale facilities.
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E.
HGF
HGF is the National Rail station code for Hag Fold railway station in Greater Manchester, England.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: platelet-derived growth factor Target entity description: Platelet-derived growth factor is a key signaling protein that regulates cell growth, proliferation, and angiogenesis, and plays important roles in wound healing and various pathological conditions such as cancer and fibrosis.
-
A.
IN-2
IN-2 is the standard postal-style abbreviation used to refer to Indiana's 2nd congressional district in the U.S. House of Representatives.
-
B.
PDG
PDG is an abbreviation commonly used for the Policy Development Group, an organization focused on formulating and advising on policy matters.
-
C.
EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
-
D.
HGF
HGF is the abbreviation for the Helmholtz Association, Germany’s largest scientific research organization spanning multiple disciplines and large-scale facilities.
-
E.
HGF
HGF is the National Rail station code for Hag Fold railway station in Greater Manchester, England.
- F. None of above. chosen
Statements (54)
| Predicate | Object |
|---|---|
| instanceOf |
cytokine
ⓘ
growth factor ⓘ mitogen ⓘ signaling protein ⓘ |
| activates |
JAK-STAT signaling pathway
NERFINISHED
ⓘ
MAPK signaling pathway NERFINISHED ⓘ PI3K-AKT signaling pathway NERFINISHED ⓘ receptor tyrosine kinases ⓘ |
| alternativeName | PDGF ⓘ |
| associatedWith |
atherosclerosis
ⓘ
cancer ⓘ diabetic retinopathy ⓘ fibrosis ⓘ idiopathic pulmonary fibrosis ⓘ pulmonary arterial hypertension ⓘ |
| bindsTo |
PDGF receptor alpha
NERFINISHED
ⓘ
PDGF receptor beta NERFINISHED ⓘ |
| composedOf |
PDGF-A chain
NERFINISHED
ⓘ
PDGF-B chain NERFINISHED ⓘ PDGF-C chain NERFINISHED ⓘ PDGF-D chain NERFINISHED ⓘ |
| discoveredIn | 1970s ⓘ |
| encodedBy |
PDGFA gene
NERFINISHED
ⓘ
PDGFB gene NERFINISHED ⓘ PDGFC gene NERFINISHED ⓘ PDGFD gene NERFINISHED ⓘ |
| forms |
PDGF-AA dimer
ⓘ
PDGF-AB dimer ⓘ PDGF-BB dimer ⓘ PDGF-CC dimer ⓘ PDGF-DD dimer ⓘ |
| foundIn | platelet alpha granules ⓘ |
| involvedIn |
embryonic development
ⓘ
tissue repair ⓘ wound healing ⓘ |
| producedBy |
endothelial cells
ⓘ
fibroblasts ⓘ macrophages ⓘ platelets ⓘ smooth muscle cells ⓘ |
| promotes |
chemotaxis of mesenchymal cells
ⓘ
pericyte recruitment ⓘ vascular remodeling ⓘ |
| regulates |
angiogenesis
ⓘ
cell growth ⓘ cell migration ⓘ cell proliferation ⓘ |
| stimulates |
extracellular matrix production
ⓘ
fibroblast proliferation ⓘ smooth muscle cell proliferation ⓘ |
| targetCellType |
fibroblasts
ⓘ
glial cells ⓘ mesenchymal cells ⓘ smooth muscle cells ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: platelet-derived growth factor Description of subject: Platelet-derived growth factor is a key signaling protein that regulates cell growth, proliferation, and angiogenesis, and plays important roles in wound healing and various pathological conditions such as cancer and fibrosis.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.