platelet-derived growth factor
E681666
Platelet-derived growth factor is a key signaling protein that regulates cell growth, proliferation, and angiogenesis, and plays important roles in wound healing and various pathological conditions such as cancer and fibrosis.
Statements (54)
| Predicate | Object |
|---|---|
| instanceOf |
cytokine
ⓘ
growth factor ⓘ mitogen ⓘ signaling protein ⓘ |
| activates |
JAK-STAT signaling pathway
NERFINISHED
ⓘ
MAPK signaling pathway NERFINISHED ⓘ PI3K-AKT signaling pathway NERFINISHED ⓘ receptor tyrosine kinases ⓘ |
| alternativeName | PDGF ⓘ |
| associatedWith |
atherosclerosis
ⓘ
cancer ⓘ diabetic retinopathy ⓘ fibrosis ⓘ idiopathic pulmonary fibrosis ⓘ pulmonary arterial hypertension ⓘ |
| bindsTo |
PDGF receptor alpha
NERFINISHED
ⓘ
PDGF receptor beta NERFINISHED ⓘ |
| composedOf |
PDGF-A chain
NERFINISHED
ⓘ
PDGF-B chain NERFINISHED ⓘ PDGF-C chain NERFINISHED ⓘ PDGF-D chain NERFINISHED ⓘ |
| discoveredIn | 1970s ⓘ |
| encodedBy |
PDGFA gene
NERFINISHED
ⓘ
PDGFB gene NERFINISHED ⓘ PDGFC gene NERFINISHED ⓘ PDGFD gene NERFINISHED ⓘ |
| forms |
PDGF-AA dimer
ⓘ
PDGF-AB dimer ⓘ PDGF-BB dimer ⓘ PDGF-CC dimer ⓘ PDGF-DD dimer ⓘ |
| foundIn | platelet alpha granules ⓘ |
| involvedIn |
embryonic development
ⓘ
tissue repair ⓘ wound healing ⓘ |
| producedBy |
endothelial cells
ⓘ
fibroblasts ⓘ macrophages ⓘ platelets ⓘ smooth muscle cells ⓘ |
| promotes |
chemotaxis of mesenchymal cells
ⓘ
pericyte recruitment ⓘ vascular remodeling ⓘ |
| regulates |
angiogenesis
ⓘ
cell growth ⓘ cell migration ⓘ cell proliferation ⓘ |
| stimulates |
extracellular matrix production
ⓘ
fibroblast proliferation ⓘ smooth muscle cell proliferation ⓘ |
| targetCellType |
fibroblasts
ⓘ
glial cells ⓘ mesenchymal cells ⓘ smooth muscle cells ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.