GABA
E675120
gamma-aminobutyric acid
inhibitory neurotransmitter
neurotransmitter
non-proteinogenic amino acid
organic compound
GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the mammalian central nervous system, crucial for reducing neuronal excitability and regulating muscle tone and anxiety.
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
gamma-aminobutyric acid
ⓘ
inhibitory neurotransmitter ⓘ neurotransmitter ⓘ non-proteinogenic amino acid ⓘ organic compound ⓘ |
| actsIn |
brain
ⓘ
central nervous system ⓘ spinal cord ⓘ |
| bindsTo |
GABA-A receptor
NERFINISHED
ⓘ
GABA-B receptor NERFINISHED ⓘ GABA-C receptor NERFINISHED ⓘ |
| chemicalFormula | C4H9NO2 ⓘ |
| effectViaGABAA |
hyperpolarizes postsynaptic membrane
ⓘ
increases chloride ion influx ⓘ |
| effectViaGABAB |
activates G-protein-coupled signaling
ⓘ
inhibits calcium channels ⓘ opens potassium channels ⓘ |
| hasFunctionalGroup |
amino group
ⓘ
carboxylic acid group ⓘ |
| hasIUPACName | 4-aminobutanoic acid ⓘ |
| hasRole |
anxiolytic modulator
ⓘ
neuromodulator ⓘ primary inhibitory neurotransmitter in the mammalian central nervous system ⓘ regulator of muscle tone ⓘ regulator of neuronal excitability ⓘ |
| isAssociatedWithDisorder |
Huntington disease
NERFINISHED
ⓘ
anxiety disorders ⓘ epilepsy ⓘ insomnia ⓘ |
| isClearedFromSynapseBy | GABA transporters ⓘ |
| isMetabolizedBy | GABA transaminase ⓘ |
| isPrimaryInhibitoryNeurotransmitterIn | mammalian central nervous system ⓘ |
| isReleasedAt | chemical synapses ⓘ |
| isReleasedBy | GABAergic neurons ⓘ |
| isReleasedInResponseTo | nerve impulse ⓘ |
| isStoredIn | synaptic vesicles ⓘ |
| isSynthesizedByEnzyme | glutamate decarboxylase ⓘ |
| isSynthesizedFrom | glutamate ⓘ |
| isTargetOfDrugClass |
barbiturates
ⓘ
gabapentinoids ⓘ |
| isTargetOfDrugClass |
benzodiazepines
ⓘ
general anesthetics ⓘ some anticonvulsants ⓘ |
| overallEffectOnNeuron | reduces neuronal excitability ⓘ |
| receptorTypeInteractedWith |
ionotropic receptor
ⓘ
metabotropic receptor ⓘ |
| regulatesProcess |
anxiety
ⓘ
muscle tone ⓘ seizure threshold ⓘ sleep ⓘ |
| requiresCofactorForSynthesis | pyridoxal phosphate ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.