norepinephrine
E655337
Norepinephrine is a neurotransmitter and hormone involved in the body’s fight-or-flight response, regulating arousal, attention, and blood pressure.
Statements (71)
| Predicate | Object |
|---|---|
| instanceOf |
catecholamine
ⓘ
hormone ⓘ neurotransmitter ⓘ |
| actsOnReceptor |
alpha-1 adrenergic receptor
NERFINISHED
ⓘ
alpha-2 adrenergic receptor NERFINISHED ⓘ beta-1 adrenergic receptor ⓘ |
| belongsToPathway |
adrenergic signaling pathway
ⓘ
catecholamine biosynthesis pathway ⓘ |
| bindsTo | G protein-coupled receptors NERFINISHED ⓘ |
| chemicalFormula | C8H11NO3 ⓘ |
| hasATCCode | C01CA03 ⓘ |
| hasCASNumber | 51-41-2 ⓘ |
| hasChirality | R-configuration at beta carbon ⓘ |
| hasFunctionalGroup |
alcohol
ⓘ
catechol ⓘ primary amine ⓘ |
| hasIUPACName | 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol ⓘ |
| hasLowAffinityFor | beta-2 adrenergic receptor ⓘ |
| hasMetabolite |
3-methoxy-4-hydroxyphenylglycol
ⓘ
MHPG ⓘ VMA ⓘ vanillylmandelic acid ⓘ |
| hasMolarMass | 169.18 g/mol ⓘ |
| hasOtherName |
(R)-(-)-norepinephrine
ⓘ
noradrenaline NERFINISHED ⓘ |
| haspKa | about 8.6 for amine group ⓘ |
| hasRouteOfAdministration | intravenous ⓘ |
| increases |
diastolic blood pressure
ⓘ
peripheral vascular resistance ⓘ systolic blood pressure ⓘ |
| isClearedBy |
NET
ⓘ
norepinephrine transporter NERFINISHED ⓘ |
| isDerivedFrom | dopamine ⓘ |
| isEndogenousTo |
humans
ⓘ
mammals ⓘ |
| isHydrophilic | true ⓘ |
| isImplicatedIn |
ADHD
NERFINISHED
ⓘ
PTSD NERFINISHED ⓘ attention-deficit hyperactivity disorder ⓘ depression ⓘ |
| isImplicatedIn | post-traumatic stress disorder ⓘ |
| isMetabolizedBy |
COMT
NERFINISHED
ⓘ
MAO-A NERFINISHED ⓘ catechol-O-methyltransferase ⓘ monoamine oxidase ⓘ |
| isPartOf | sympathetic nervous system NERFINISHED ⓘ |
| isPolar | true ⓘ |
| isPrecursorOf | epinephrine ⓘ |
| isReleasedFrom |
adrenal medulla
ⓘ
locus coeruleus NERFINISHED ⓘ sympathetic nerve terminals ⓘ |
| isStoredIn | synaptic vesicles ⓘ |
| isStoredWith |
ATP in vesicles
ⓘ
chromogranins in vesicles ⓘ |
| isSynthesizedByEnzyme | dopamine beta-hydroxylase NERFINISHED ⓘ |
| isSynthesizedFrom |
L-DOPA
ⓘ
L-tyrosine ⓘ dopamine ⓘ |
| isUsedAs | vasopressor drug ⓘ |
| isUsedToTreat |
hypotension
ⓘ
septic shock ⓘ |
| mediates | fight-or-flight response ⓘ |
| modulates |
anxiety
ⓘ
mood ⓘ stress response ⓘ |
| regulates |
arousal
ⓘ
attention ⓘ blood pressure ⓘ heart rate ⓘ vascular tone ⓘ vigilance ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.