Hershey–Chase experiment

E629010

landmark experiment molecular biology experiment scientific experiment

The Hershey–Chase experiment was a landmark 1952 study in molecular biology that used bacteriophages to demonstrate that DNA, rather than protein, is the genetic material.

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Observed surface forms (2)

Surface form	Occurrences
Hershey–Chase experiment paper	1
Hershey–Chase research team	1

Statements (47)

Predicate	Object
instanceOf	landmark experiment ⓘ molecular biology experiment ⓘ scientific experiment ⓘ
alsoKnownAs	blender experiment NERFINISHED ⓘ
associatedWith	Alfred Hershey Nobel Prize in Physiology or Medicine 1969 NERFINISHED ⓘ
author	Alfred Hershey NERFINISHED ⓘ Martha Chase NERFINISHED ⓘ
conclusion	DNA carries hereditary information in phages ⓘ genetic continuity is based on DNA replication ⓘ
country	United States of America ⓘ surface form: United States
dataType	radioactivity measurements ⓘ
demonstrated	DNA is the genetic material NERFINISHED ⓘ protein is not the hereditary material in bacteriophage T2 ⓘ
evidenceType	experimental evidence ⓘ
field	genetics ⓘ molecular biology ⓘ virology ⓘ
historicalSignificance	helped establish modern molecular biology ⓘ
influenced	acceptance of DNA as genetic material in all organisms ⓘ development of molecular genetics ⓘ
keyConcept	DNA-protein distinction ⓘ genetic material ⓘ radioisotope labeling ⓘ viral replication ⓘ
method	differential radioactive labeling of DNA and protein ⓘ infection of bacteria with labeled phages ⓘ physical separation of phage coats from infected cells ⓘ
organismStudied	Escherichia coli K-12 NERFINISHED ⓘ bacteriophage T2 NERFINISHED ⓘ
performedAt	Cold Spring Harbor Laboratory NERFINISHED ⓘ
preceded	Nobel Prize in Physiology or Medicine 1969 for work on bacteriophages NERFINISHED ⓘ
publicationYear	1952 ⓘ
relatedTo	Avery–MacLeod–McCarty experiment NERFINISHED ⓘ Watson–Crick model of DNA NERFINISHED ⓘ
showed	phage DNA enters bacterial cells during infection ⓘ phage protein coats largely remain outside bacterial cells ⓘ
supportsTheory	DNA as universal genetic material ⓘ
testedMaterial	DNA ⓘ protein ⓘ
timePeriod	early 1950s ⓘ
uses	Escherichia coli NERFINISHED ⓘ bacteriophage T2 NERFINISHED ⓘ blender ⓘ centrifuge ⓘ radioactive phosphorus-32 ⓘ radioactive sulfur-35 ⓘ
year	1952 ⓘ

Referenced by (6)

Full triples — surface form annotated when it differs from this entity's canonical label.

Phage Group → contributedTo → Hershey–Chase experiment ⓘ

Martha Chase → notableWork → Hershey–Chase experiment ⓘ

Martha Chase → knownFor → Hershey–Chase experiment ⓘ

Martha Chase → coAuthorOf → Hershey–Chase experiment ⓘ

this entity surface form: Hershey–Chase experiment paper

Martha Chase → partOf → Hershey–Chase experiment ⓘ

this entity surface form: Hershey–Chase research team

Alfred Hershey → notableWork → Hershey–Chase experiment ⓘ